| Tag | Content |
|---|
| CPLM ID | CPLM-010950 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Unconventional myosin-Va |
Protein Synonyms/Alias | Dilute myosin heavy chain, non-muscle; Myosin heavy chain p190; Myosin-V |
Gene Name | MYO5A |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Gallus gallus (Chicken) |
NCBI Taxa ID | 9031 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 210 | MESIGNAKTTRNDNS | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation (By similarity). |
Sequence Annotation | DOMAIN 1 766 Myosin head-like.
DOMAIN 767 789 IQ 1.
DOMAIN 790 814 IQ 2.
DOMAIN 815 837 IQ 3.
DOMAIN 838 862 IQ 4.
DOMAIN 863 887 IQ 5.
DOMAIN 888 915 IQ 6.
DOMAIN 1508 1784 Dilute.
NP_BIND 163 170 ATP (By similarity).
REGION 644 666 Actin-binding (Potential).
MOD_RES 1734 1734 Phosphothreonine (Potential). |
Keyword | 3D-structure; Actin-binding; ATP-binding; Calmodulin-binding; Coiled coil; Complete proteome; Direct protein sequencing; Golgi apparatus; Membrane; Motor protein; Myosin; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1829 AA |
Protein Sequence | MAASELYTKY ARVWIPDPEE VWKSAELLKD YKPGDKVLQL RLEEGKDLEY CLDPKTKELP 60
PLRNPDILVG ENDLTALSYL HEPAVLHNLK VRFIDSKLIY TYCGIVLVAI NPYEQLPIYG 120
EDIINAYSGQ NMGDMDPHIF AVAEEAYKQM ARDERNQSII VSGESGAGKT VSAKYAMRYF 180
ATVSGSASEA NVEEKVLASN PIMESIGNAK TTRNDNSSRF GKYIEIGFDK RYRIIGANMR 240
TYLLEKSRVV FQAEEERNYH IFYQLCASAA LPEFKTLRLG NANYFHYTKQ GGSPVIDGID 300
DAKEMVNTRQ ACTLLGISDS YQMGIFRILA GILHLGNVEF ASRDSDSCAI PPKHDPLTIF 360
CDLMGVDYEE MAHWLCHRKL ATATETYIKP ISKLHAINAR DALAKHIYAN LFNWIVDHVN 420
KALHSTVKQH SFIGVLDIYG FETFEINSFE QFCINYANEK LQQQFNMHVF KLEQEEYMKE 480
QIPWTLIDFY DNQPCINLIE AKMGVLDLLD EECKMPKGSD DTWAQKLYNT HLNKCALFEK 540
PRLSNKAFII KHFADKVEYQ CEGFLEKNKD TVYEEQIKVL KSSKKFKLLP ELFQDEEKAI 600
SPTSATPSGR VPLSRTPVKP AKARPGQTSK EHKKTVGHQF RNSLHLLMET LNATTPHYVR 660
CIKPNDFKFP FTFDEKRAVQ QLRACGVLET IRISAAGFPS RWTYQEFFSR YRVLMKQKDV 720
LSDRKQTCKN VLEKLILDKD KYQFGKTKIF FRAGQVAYLE KIRADKLRAA CIRIQKTIRG 780
WLMRKKYMRM RRAAITIQRY VRGHQARCYA TFLRRTRAAI IIQKFQRMYV VRKRYQCMRD 840
ATIALQALLR GYLVRNKYQM MLREHKSIII QKHVRGWLAR VHYHRTLKAI VYLQCCYRRM 900
MAKRELKKLK IEARSVERYK KLHIGLENKI MQLQRKIDEQ NKEYKSLLEK MNNLEITYST 960
ETEKLRSDVE RLRMSEEEAK NATNRVLSLQ EEIAKLRKEL HQTQTEKKTI EEWADKYKHE 1020
TEQLVSELKE QNTLLKTEKE ELNRRIHDQA KEITETMEKK LVEETKQLEL DLNDERLRYQ 1080
NLLNEFSRLE ERYDDLKDEM NLMVSIPKPG HKRTDSTHSS NESEYTFSSE ITEAEDLPLR 1140
MEEPSEKKAP LDMSLFLKLQ KRVTELEQEK QSLQDELDRK EEQALRAKAK EEERPPIRGA 1200
ELEYESLKRQ ELESENKKLK NELNELQKAL TETRAPEVTA PGAPAYRVLL DQLTSVSEEL 1260
EVRKEEVLIL RSQLVSQKEA IQPKEDKNTM TDSTILLEDV QKMKDKGEIA QAYIGLKETN 1320
RLLESQLQSQ KKSHENELES LRGEIQSLKE ENNRQQQLLA QNLQLPPEAR IEASLQHEIT 1380
RLTNENLDLM EQLEKQDKTV RKLKKQLKVF AKKIGELEVG QMENISPGQI IDEPIRPVNI 1440
PRKEKDFQGM LEYKKEDEQK LVKNLILELK PRGVAVNLIP GLPAYILFMC VRHADYLNDD 1500
QKVRSLLTST INGIKKVLKK RGDDFETVSF WLSNTCRFLH CLKQYSGEEG FMKHNTPRQN 1560
EHCLTNFDLA EYRQVLSDLA IQIYQQLVRV LENILQPMIV SGMLEHETIQ GVSGVKPTGL 1620
RKRTSSIADE GTYTLDSIIR QLNSFHSVMC QHGMDPELIK QVVKQMFYII GAVTLNNLLL 1680
RKDMCSWSKG MQIRYNVSQL EEWLRDKNLM NSGAKETLEP LIQAAQLLQV KKKTDEDAEA 1740
ICSMCNALTT AQIVKVLNLY TPVNEFEERV LVSFIRTIQL RLRDRKDSPQ LLMDAKHIFP 1800
VTFPFNPSSL ALETIQIPAS LGLGFISRV 1829 |
Gene Ontology | GO:0031941; C:filamentous actin; IDA:UniProtKB. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0032593; C:insulin-responsive compartment; ISS:UniProtKB. GO:0016459; C:myosin complex; IEA:UniProtKB-KW. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0060001; F:minus-end directed microfilament motor activity; IDA:UniProtKB. GO:0032869; P:cellular response to insulin stimulus; ISS:UniProtKB. GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB. GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |