CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002540
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 T-cell surface glycoprotein CD3 epsilon chain 
Protein Synonyms/Alias
 T-cell surface antigen T3/Leu-4 epsilon chain; CD3e 
Gene Name
 CD3E 
Gene Synonyms/Alias
 T3E 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
73IGGDEDDKNIGSDEDubiquitination[1]
85DEDHLSLKEFSELEQubiquitination[1]
104VCYPRGSKPEDANFYubiquitination[1, 2]
177GRQRGQNKERPPPVPubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 The CD3 complex mediates signal transduction. 
Sequence Annotation
 DOMAIN 32 112 Ig-like.
 DOMAIN 178 205 ITAM.
 MOD_RES 188 188 Phosphotyrosine.
 MOD_RES 199 199 Phosphotyrosine.
 DISULFID 49 98  
Keyword
 3D-structure; Complete proteome; Disulfide bond; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 207 AA 
Protein Sequence
MQSGTHWRVL GLCLLSVGVW GQDGNEEMGG ITQTPYKVSI SGTTVILTCP QYPGSEILWQ 60
HNDKNIGGDE DDKNIGSDED HLSLKEFSEL EQSGYYVCYP RGSKPEDANF YLYLRARVCE 120
NCMEMDVMSV ATIVIVDICI TGGLLLLVYY WSKNRKAKAK PVTRGAGAGG RQRGQNKERP 180
PPVPNPDYEP IRKGQRDLYS GLNQRRI 207 
Gene Ontology
 GO:0042105; C:alpha-beta T cell receptor complex; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0001772; C:immunological synapse; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0042101; C:T cell receptor complex; NAS:UniProtKB.
 GO:0019901; F:protein kinase binding; NAS:UniProtKB.
 GO:0030159; F:receptor signaling complex scaffold activity; NAS:UniProtKB.
 GO:0005057; F:receptor signaling protein activity; TAS:ProtInc.
 GO:0042608; F:T cell receptor binding; NAS:UniProtKB.
 GO:0004888; F:transmembrane signaling receptor activity; NAS:UniProtKB.
 GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.
 GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Compara.
 GO:0045060; P:negative thymic T cell selection; IEA:Compara.
 GO:0046641; P:positive regulation of alpha-beta T cell proliferation; IEA:Compara.
 GO:0050850; P:positive regulation of calcium-mediated signaling; IEA:Compara.
 GO:0032729; P:positive regulation of interferon-gamma production; IEA:Compara.
 GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Compara.
 GO:0032753; P:positive regulation of interleukin-4 production; IEA:Compara.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Compara.
 GO:0002669; P:positive regulation of T cell anergy; IEA:Compara.
 GO:0042102; P:positive regulation of T cell proliferation; IMP:UniProtKB.
 GO:0042981; P:regulation of apoptotic process; NAS:UniProtKB.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0007172; P:signal complex assembly; TAS:ProtInc.
 GO:0042110; P:T cell activation; NAS:UniProtKB.
 GO:0031295; P:T cell costimulation; TAS:Reactome.
 GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
 GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:ProtInc. 
Interpro
 IPR015477; CD3_epsilon.
 IPR013783; Ig-like_fold.
 IPR003598; Ig_sub2.
 IPR003110; Phos_immunorcpt_sig_ITAM. 
Pfam
 PF02189; ITAM 
SMART
 SM00408; IGc2
 SM00077; ITAM 
PROSITE
 PS50835; IG_LIKE
 PS51055; ITAM_1 
PRINTS