CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030885
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear receptor corepressor 1 
Protein Synonyms/Alias
 cDNA FLJ52302, highly similar to Nuclear receptor corepressor 1 
Gene Name
 NCOR1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
95DVTISSNKSTNHERKubiquitination[1, 2]
424QMDVSKTKESKHEAAubiquitination[1]
453EQQQLEQKTLEVEKRubiquitination[1, 2]
459QKTLEVEKRSVQCLYubiquitination[1, 2]
529TRQIASDKDARERGSacetylation[2]
582TYQPEVVKANQAENDubiquitination[1, 2, 3, 4]
790ENTSPMVKSKKQEIFubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Receptor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1024 AA 
Protein Sequence
MPPLEIVPEN IKVVERGKYE DVKAGETVRS RHTSVVSSGP SVLRSTLHEA PKAQLSPGIY 60
DDTSARRTPV SYQNTMSRGS PMMNRTSDVT ISSNKSTNHE RKSTLTPTQR ESIPAKSPVP 120
GVDPVVSHSP FDPHHRGSTA GEVYRSHLPT HLDPAMPFHR ALDPAAAAYL FQRQLSPTPG 180
YPSQYQLYAM ENTRQTILND YITSQQMQVN LRPDVARGLS PREQPLGLPY PATRGIIDLT 240
NMPPTILVPH PGGTSTPPMD RITYIPGTQI TFPPRPYNSA SMSPGHPTHL AAAASAERER 300
EREREKERER ERIAAASSDL YLRPGSEQPG RPGSHGYVRS PSPSVRTQET MLQQRPSVFQ 360
GTNGTSVITP LDPTAQLRIM PLPAGGPSIS QGLPASRYNT AADALAALVD AAASAPQMDV 420
SKTKESKHEA ARLEENLRSR SAAVSEQQQL EQKTLEVEKR SVQCLYTSSA FPSGKPQPHS 480
SVVYSEAGKD KGPPPKSRYE EELRTRGKTT ITAANFIDVI ITRQIASDKD ARERGSQSSD 540
SSSSLSSHRY ETPSDAIEVI SPASSPAPPQ EKLQTYQPEV VKANQAENDP TRQYEGPLHH 600
YRPQQESPSP QQQLPPSSQA EGMGQVPRTH RLITLADHIC QIITQDFARN QVSSQTPQQP 660
PTSTFQNSPS ALVSTPVRTK TSNRYSPESQ AQSVHHQRPG SRVSPENLVD KSRGSRPGKS 720
PERSHVSSEP YEPISPPQVP VVHEKQDSLL LLSQRGAEPA EQRNDARSPG SISYLPSFFT 780
KLENTSPMVK SKKQEIFRKL NSSGGGDSDM AAAQPGTEIF NLPAVTTSGS VSSRGHSFAD 840
PASNLGLEDI IRKALMGSFD DKVEDHGVVM SQPMGVVPGT ANTSVVTSGE TRREEGDPSP 900
HSGGVCKPKL ISKSNSRKSK SPIPGQGYLG TERPSSVSSV HSEGDYHRQT PGWAWEDRPS 960
STGSTQFPYN PLTMRMLSST PPTPIACAPS AVNQAAPHQQ NRIWEREPAP LLSAQYETLS 1020
DSDD 1024 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0017053; C:transcriptional repressor complex; IEA:Compara.
 GO:0035033; F:histone deacetylase regulator activity; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0002361; P:CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0032922; P:circadian regulation of gene expression; IEA:Compara.
 GO:0060318; P:definitive erythrocyte differentiation; IEA:Compara.
 GO:0014067; P:negative regulation of phosphatidylinositol 3-kinase cascade; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0031065; P:positive regulation of histone deacetylation; IEA:Compara.
 GO:0040014; P:regulation of multicellular organism growth; IEA:Compara.
 GO:0021794; P:thalamus development; IEA:Compara. 
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Pfam
  
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PRINTS