CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015164
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-box only protein 42 
Protein Synonyms/Alias
 Just one F-box and Kelch domain-containing protein 
Gene Name
 FBXO42 
Gene Synonyms/Alias
 FBX42; JFK; KIAA1332 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
159WRLDLNSKEWIRPLAubiquitination[1, 2]
493RGSLPDQKDLRLGSIubiquitination[1, 2]
507IDLNWDLKPASSSNPubiquitination[1]
564RRSLEAIKAMSSKGPubiquitination[1, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266] 
Functional Description
 Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. 
Sequence Annotation
 DOMAIN 44 93 F-box.
 REPEAT 132 184 Kelch 1.
 REPEAT 186 242 Kelch 2.
 REPEAT 244 293 Kelch 3.
 REPEAT 295 342 Kelch 4.
 MOD_RES 365 365 Phosphoserine.
 MOD_RES 373 373 Phosphoserine.
 MOD_RES 378 378 Phosphothreonine.
 MOD_RES 488 488 Phosphoserine (By similarity).
 MOD_RES 552 552 Phosphoserine.  
Keyword
 Complete proteome; Kelch repeat; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 717 AA 
Protein Sequence
MASSSDSEDD SFMAVDQEET VLEGTMDQDE EPHPVLEAEE TRHNRSMSEL PEEVLEYILS 60
FLSPYQEHKT AALVCKQWYR LIKGVAHQCY HGFMKAVQEG NIQWESRTYP YPGTPITQRF 120
SHSACYYDAN QSMYVFGGCT QSSCNAAFND LWRLDLNSKE WIRPLASGSY PSPKAGATLV 180
VYKDLLVLFG GWTRPSPYPL HQPERFFDEI HTYSPSKNWW NCIVTTHGPP PMAGHSSCVI 240
DDKMIVFGGS LGSRQMSNDV WVLDLEQWAW SKPNISGPSP HPRGGQSQIV IDDATILILG 300
GCGGPNALFK DAWLLHMHSG PWAWQPLKVE NEEHGAPELW CHPACRVGQC VVVFSQAPSG 360
RAPLSPSLNS RPSPISATPP ALVPETREYR SQSPVRSMDE APCVNGRWGT LRPRAQRQTP 420
SGSREGSLSP ARGDGSPILN GGSLSPGTAA VGGSSLDSPV QAISPSTPSA PEGYDLKIGL 480
SLAPRRGSLP DQKDLRLGSI DLNWDLKPAS SSNPMDGMDN RTVGGSMRHP PEQTNGVHTP 540
PHVASALAGA VSPGALRRSL EAIKAMSSKG PSASAALSPP LGSSPGSPGS QSLSSGETVP 600
IPRPGPAQGD GHSLPPIARR LGHHPPQSLN VGKPLYQSMN CKPMQMYVLD IKDTKEKGRV 660
KWKVFNSSSV VGPPETSLHT VVQGRGELII FGGLMDKKQN VKYYPKTNAL YFVRAKR 717 
Gene Ontology
  
Interpro
 IPR001810; F-box_dom_cyclin-like.
 IPR015915; Kelch-typ_b-propeller.
 IPR011498; Kelch_2. 
Pfam
 PF07646; Kelch_2 
SMART
 SM00256; FBOX 
PROSITE
 PS50181; FBOX 
PRINTS