| Tag | Content |
|---|
| CPLM ID | CPLM-012132 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Acid ceramidase |
Protein Synonyms/Alias | AC; ACDase; Acid CDase; Acylsphingosine deacylase; N-acylsphingosine amidohydrolase; Putative 32 kDa heart protein; PHP32; Acid ceramidase subunit alpha; Acid ceramidase subunit beta |
Gene Name | ASAH1 |
Gene Synonyms/Alias | ASAH; HSD-33; HSD33 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 108 | NTFVPSGKIMQVVDE | ubiquitination | [1] |
|
Reference | [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. |
Sequence Annotation | CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
CARBOHYD 195 195 N-linked (GlcNAc...) (Potential).
CARBOHYD 259 259 N-linked (GlcNAc...).
CARBOHYD 286 286 N-linked (GlcNAc...).
CARBOHYD 342 342 N-linked (GlcNAc...) (Potential).
CARBOHYD 348 348 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Epilepsy; Glycoprotein; Hydrolase; Lysosome; Neurodegeneration; Polymorphism; Reference proteome; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 395 AA |
Protein Sequence | MNCCIGLGEK ARGSHRASYP SLSALFTEAS ILGFGSFAVK AQWTEDCRKS TYPPSGPTYR 60
GAVPWYTINL DLPPYKRWHE LMLDKAPVLK VIVNSLKNMI NTFVPSGKIM QVVDEKLPGL 120
LGNFPGPFEE EMKGIAAVTD IPLGEIISFN IFYELFTICT SIVAEDKKGH LIHGRNMDFG 180
VFLGWNINND TWVITEQLKP LTVNLDFQRN NKTVFKASSF AGYVGMLTGF KPGLFSLTLN 240
ERFSINGGYL GILEWILGKK DVMWIGFLTR TVLENSTSYE EAKNLLTKTK ILAPAYFILG 300
GNQSGEGCVI TRDRKESLDV YELDAKQGRW YVVQTNYDRW KHPFFLDDRR TPAKMCLNRT 360
SQENISFETM YDVLSTKPVL NKLTVYTTLI DVTKGQFETY LRDCPDPCIG W 411 |
Gene Ontology | GO:0043202; C:lysosomal lumen; TAS:Reactome. GO:0017040; F:ceramidase activity; TAS:Reactome. GO:0008219; P:cell death; IEA:UniProtKB-KW. GO:0006672; P:ceramide metabolic process; TAS:ProtInc. GO:0006687; P:glycosphingolipid metabolic process; TAS:Reactome. GO:0030324; P:lung development; IEA:Compara. GO:0010033; P:response to organic substance; IEA:Compara. GO:0044281; P:small molecule metabolic process; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |