UniProt Accession

 SLG1_YEAST; P54867; D6W274 

Genbank Protein ID

 U39481; U43491; Z74916; BK006948 

Genbank Nucleotide ID

 AAA85862.1; AAC49488.1; CAA99196.1; DAA10790.1 

Protein Name

 Protein SLG1 

Protein Synonyms/Alias

 Cell wall integrity and stress response component 1; Synthetic lethal with GAP protein 1 

Gene Name

 SLG1 

Gene Synonyms/Alias

 WSC1; YOR008C; UNF378 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
315	KPVEYPDKLYASSFS	ubiquitination	[1]
338	SFEEEHTKGQTDINP	ubiquitination	[1]
365	INGGPGGKNNVLTVV	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Plays a role during G1 to regulate entering or exiting the cell cycle. Involved in stress responses. Has a role in cell wall integrity signaling. Activates ROM1 or ROM2 catalyzed guanine nucleotide exchange toward RHO1. Important regulator of the actin cytoskeleton rearrangements in conditions of cell wall expansion and membrane stretching. Specifically required for the actin reorganization induced by hypo-osmotic shock. Multicopy suppressor of 1,3-beta-glucan synthase (GS). Activates GS upstream of RHO1. Acts positively on the PKC1-MAPK pathway. Activates transiently SLT2 during alkaline stress, which leads to an increase in the expression of several specific genes. 

Sequence Annotation

 DOMAIN 22 110 WSC.
 MOD_RES 331 331 Phosphoserine.
 MOD_RES 353 353 Phosphoserine.
 MOD_RES 356 356 Phosphothreonine.
 CARBOHYD 65 65 N-linked (GlcNAc...) (Potential).  

Keyword

 Cell cycle; Cell membrane; Cell wall biogenesis/degradation; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Signal; Stress response; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 378 AA 

Protein Sequence

Gene Ontology

 GO:0005935; C:cellular bud neck; IDA:SGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043332; C:mating projection tip; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0004888; F:transmembrane signaling receptor activity; IGI:SGD.
 GO:0030036; P:actin cytoskeleton organization; IMP:SGD.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0030010; P:establishment of cell polarity; IMP:SGD.
 GO:0031505; P:fungal-type cell wall organization; IMP:SGD.
 GO:0030242; P:peroxisome degradation; IMP:SGD.
 GO:0045807; P:positive regulation of endocytosis; IMP:SGD.
 GO:0009408; P:response to heat; IMP:SGD.
 GO:0006970; P:response to osmotic stress; IGI:SGD.
 GO:0007266; P:Rho protein signal transduction; IMP:SGD. 

Interpro

 IPR002889; WSC_carb-bd.
 IPR013994; WSC_carb-bd_subgr. 

Pfam

 PF01822; WSC 

SMART

 SM00321; WSC 

PROSITE

 PS51212; WSC 

PRINTS