UniProt Accession

 STMN1_MOUSE; P54227 

Genbank Protein ID

 L20256; L20257; L20258; X94915; BC010581; BC031831; BC054396 

Genbank Nucleotide ID

 CAA64401.1; AAH10581.1; AAH31831.1; AAH54396.1 

Protein Name

 Stathmin 

Protein Synonyms/Alias

 Leukemia-associated gene protein; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17 

Gene Name

 Stmn1 

Gene Synonyms/Alias

 Lag; Lap18; Pr22 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
29	LILSPRSKESVPDFP	ubiquitination	[1]
52	LSLEEIQKKLEAAEE	ubiquitination	[1]
128	ERLREKDKHVEEVRK	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis (By similarity). Involved in the control of the learned and innate fear. 

Sequence Annotation

 DOMAIN 4 145 SLD.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 9 9 N6-acetyllysine (By similarity).
 MOD_RES 16 16 Phosphoserine; by PKA.
 MOD_RES 25 25 Phosphoserine; by CDK1, MAPK1 and MAPK3.
 MOD_RES 31 31 Phosphoserine (By similarity).
 MOD_RES 38 38 Phosphoserine; by CDK1, MAPK1 and MAPK3.
 MOD_RES 46 46 Phosphoserine.
 MOD_RES 63 63 Phosphoserine; by PKA.
 MOD_RES 95 95 N6-acetyllysine (By similarity).
 MOD_RES 100 100 N6-acetyllysine (By similarity).
 MOD_RES 119 119 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Direct protein sequencing; Microtubule; Neurogenesis; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 149 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:MGI.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0007409; P:axonogenesis; IMP:MGI.
 GO:0007019; P:microtubule depolymerization; IEA:Compara.
 GO:0007052; P:mitotic spindle organization; IEA:Compara.
 GO:0031115; P:negative regulation of microtubule polymerization; IDA:MGI.
 GO:0051272; P:positive regulation of cellular component movement; IGI:MGI.
 GO:0009615; P:response to virus; IEA:Compara. 

Interpro

 IPR000956; Stathmin_fam. 

Pfam

 PF00836; Stathmin 

SMART

  

PROSITE

 PS00563; STATHMIN_1
 PS01041; STATHMIN_2
 PS51663; STATHMIN_3 

PRINTS

 PR00345; STATHMIN.