| Tag | Content |
|---|
| CPLM ID | CPLM-008659 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pre-mRNA-splicing factor SYF2 |
Protein Synonyms/Alias | PRP19 complex protein 31; Synthetic lethal with CDC40 protein 2 |
Gene Name | SYF2 |
Gene Synonyms/Alias | NTC31; YGR129W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 199 | VESFINDKNKQFNEK | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Involved in pre-mRNA splicing and cell cycle control. As a component of the NTC complex (or PRP19-associated complex), associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. The cell cycle arrest of SYF2 defective cells may be due to the inefficient splicing of TUB1. |
Sequence Annotation | MOD_RES 45 45 Phosphoserine.
MOD_RES 124 124 Phosphoserine.
MOD_RES 125 125 Phosphoserine. |
Keyword | Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 215 AA |
Protein Sequence | MDFYKLDEKL KELKRKRVDV SIKSRKLADR EIQEVSANRK PRVYSMEDVN DADESVGDTE 60
SPEKEKAFHY TVQEYDAWER RHPQGKTGQS QRGGISYDQL AKLSYEKTLR NLATQTQNSS 120
KQDSSADEED NKNVPKKGRI GKVQKDTKTG KITIADDDKL VNKLAVSLQS ESKKRYEARK 180
RQMQNAKTLY GVESFINDKN KQFNEKLSRE SKGSE 215 |
Gene Ontology | GO:0005829; C:cytosol; IDA:SGD. GO:0000974; C:Prp19 complex; IDA:SGD. GO:0071006; C:U2-type catalytic step 1 spliceosome; IDA:SGD. GO:0071007; C:U2-type catalytic step 2 spliceosome; IDA:SGD. GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IDA:SGD. GO:0071004; C:U2-type prespliceosome; IDA:SGD. GO:0000398; P:mRNA splicing, via spliceosome; IMP:SGD. |
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