| Tag | Content |
|---|
| CPLM ID | CPLM-024246 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Proteasome-associated ATPase |
Protein Synonyms/Alias | AAA ATPase forming ring-shaped complexes; ARC; Mycobacterial proteasome ATPase |
Gene Name | mpa |
Gene Synonyms/Alias | MSMEG_3902; MSMEI_3813 |
Created Date | July 27, 2013 |
Organism | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) |
NCBI Taxa ID | 246196 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 595 | IRTLVTGKSSSASRA | pupylation | [1] |
|
Reference | [1] Expansion of the mycobacterial "PUPylome". Watrous J, Burns K, Liu WT, Patel A, Hook V, Bafna V, Barry CE 3rd, Bark S, Dorrestein PC. Mol Biosyst. 2010 Feb;6(2):376-85. [ PMID: 20094657] |
Functional Description | ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity). |
Sequence Annotation | NP_BIND 300 305 ATP (By similarity).
REGION 612 613 Docks into pockets in the proteasome
CROSSLNK 595 595 Isoglutamyl lysine isopeptide (Lys-Gln) |
Keyword | ATP-binding; Chaperone; Coiled coil; Complete proteome; Isopeptide bond; Nucleotide-binding; Proteasome; Reference proteome; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 613 AA |
Protein Sequence | MSESERSEGF PEGFAGAGSG SLSSEDAAEL EALRREAAML REQLENAVGP QSGLRSARDV 60
HQLEARIDSL AARNAKLMDT LKEARQQLLA LREEVDRLGQ PPSGYGVLLA THDDDTVDVF 120
TSGRKMRLTC SPNIEVKELK QGQTVRLNEA LTVVEAGNFE AVGEISTLRE ILADGHRALV 180
VGHADEERIV WLAEPLVAAK DLPDEPTDYF DDSRPRKLRP GDSLLVDTKA GYAFERIPKA 240
EVEDLVLEEV PDVSYNDIGG LGRQIEQIRD AVELPFLHKD LYKEYSLRPP KGVLLYGPPG 300
CGKTLIAKAV ANSLAKKMAE VRGDDAREAK SYFLNIKGPE LLNKFVGETE RHIRLIFQRA 360
REKASEGTPV IVFFDEMDSI FRTRGTGVSS DVETTVVPQL LSEIDGVEGL ENVIVIGASN 420
REDMIDPAIL RPGRLDVKIK IERPDAEAAQ DIFSKYLTED LPVHADDLTE FNGDRALCIK 480
AMIEKVVDRM YAEIDDNRFL EVTYANGDKE VMYFKDFNSG AMIQNVVDRA KKYAIKSVLE 540
TGQKGLRIQH LLDSIVDEFA ENEDLPNTTN PDDWARISGK KGERIVYIRT LVTGKSSSAS 600
RAIDTESNLG QYL 613 |
Gene Ontology | GO:0022623; C:proteasome-activating nucleotidase complex; IEA:HAMAP. GO:0005524; F:ATP binding; IEA:HAMAP. GO:0016887; F:ATPase activity; IEA:HAMAP. GO:0019941; P:modification-dependent protein catabolic process; IEA:HAMAP. GO:0010498; P:proteasomal protein catabolic process; IEA:HAMAP. GO:0043335; P:protein unfolding; IEA:HAMAP. |
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Pfam | |
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PRINTS | |