UniProt Accession

 PRS6B_MOUSE; P54775; Q6ZWN9 

Genbank Protein ID

 L76223; AB040869; AK077507; AK153991; AK160718; AK167041; CH466593; BC012708 

Genbank Nucleotide ID

 AAA88243.1; BAB16348.1; BAC36835.1; BAE32301.1; BAE35967.1; BAE39209.1; EDL24160.1; AAH12708.1 

Protein Name

 26S protease regulatory subunit 6B 

Protein Synonyms/Alias

 26S proteasome AAA-ATPase subunit RPT3; CIP21; MB67-interacting protein; MIP224; Proteasome 26S subunit ATPase 4; Tat-binding protein 7; TBP-7 

Gene Name

 Psmc4 

Gene Synonyms/Alias

 Tbp7 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
70	DEQKNLKKEFLHAQE	ubiquitination	[1]
159	MMLTSDQKPDVMYAD	acetylation	[2]
238	VGSEFVQKYLGEGPR	acetylation	[3, 4]
238	VGSEFVQKYLGEGPR	ubiquitination	[1]
255	RDVFRLAKENAPAII	ubiquitination	[1]
273	EIDAIATKRFDAQTG	ubiquitination	[1]
397	NRYIVLAKDFEKAYK	acetylation	[3]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. 

Sequence Annotation

 NP_BIND 206 213 ATP (Potential).
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 21 21 Phosphoserine (By similarity).
 MOD_RES 28 28 Phosphoserine (By similarity).
 MOD_RES 397 397 N6-acetyllysine (By similarity).
 MOD_RES 401 401 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Nucleus; Phosphoprotein; Proteasome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 418 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0022624; C:proteasome accessory complex; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0001824; P:blastocyst development; IMP:MGI.
 GO:0030163; P:protein catabolic process; IEA:InterPro. 

Interpro

 IPR005937; 26S_Psome_P45.
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00004; AAA 

SMART

 SM00382; AAA 

PROSITE

 PS00674; AAA 

PRINTS