CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010098
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Pyruvate dehydrogenase E1 component subunit alpha 
Protein Synonyms/Alias
  
Gene Name
 pdhA 
Gene Synonyms/Alias
 MPN_393; MP445 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
8MAILIKNKVPTTLYQacetylation[1]
29KLMDPNHKITLSNEQacetylation[1]
38TLSNEQLKHAFYLMNacetylation[1]
52NLSRIMDKKMLVWQRacetylation[1]
121NGNENGSKIEAKYKTacetylation[1]
125NGSKIEAKYKTLPINacetylation[1]
202FAISTRTKLESAVSDacetylation[1]
274DPSIYRTKEEEAEAMacetylation[1]
282EEEAEAMKSDPVKRLacetylation[1]
340VFDYNYEKLTPDLARacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Glycolysis; Oxidoreductase; Pyruvate; Reference proteome; Thiamine pyrophosphate. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 358 AA 
Protein Sequence
MAILIKNKVP TTLYQVYDNE GKLMDPNHKI TLSNEQLKHA FYLMNLSRIM DKKMLVWQRA 60
GKMLNFAPNL GEEALQVGMG MGLNENDWFC PTFRSGALML YRGVKPEQLL LYWNGNENGS 120
KIEAKYKTLP INITIGAQYS HAAGLGYMLH YKKLPNVAVT MIGDGGTAEG EFYEAMNIAS 180
IHKWNSVFCI NNNQFAISTR TKLESAVSDL STKAIAVNIP RIRVDGNDLI ASYEAMHEAA 240
NYARSGNGPV LIEFFSWRQG PHTTSDDPSI YRTKEEEAEA MKSDPVKRLR NFLFDRGILT 300
PQQEEEMVAK IEQEVQAAYE VMVSKTPVTL DEVFDYNYEK LTPDLARQKA EAKKYFKD 358 
Gene Ontology
 GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:EC.
 GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001017; DH_E1.
 IPR017596; Pyrv_DH_E1_asu_subgrp-x. 
Pfam
 PF00676; E1_dh 
SMART
  
PROSITE
  
PRINTS