CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016973
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 L-seryl-tRNA(Sec) kinase 
Protein Synonyms/Alias
 O-phosphoseryl-tRNA(Sec) kinase 
Gene Name
 PSTK 
Gene Synonyms/Alias
 C10orf89 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
261AEDNMEQKDTDRIICubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity). 
Sequence Annotation
 NP_BIND 25 32 ATP (Potential).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Kinase; Magnesium; Nucleotide-binding; Polymorphism; Protein biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 348 AA 
Protein Sequence
MKTAENIRGT GSDGPRKRGL CVLCGLPAAG KSTFARALAH RLQQEQGWAI GVVAYDDVMP 60
DAFLAGARAR PAPSQWKLLR QELLKYLEYF LMAVINGCQM SVPPNRTEAM WEDFITCLKD 120
QDLIFSAAFE AQSCYLLTKT AVSRPLFLVL DDNFYYQSMR YEVYQLARKY SLGFCQLFLD 180
CPLETCLQRN GQRPQALPPE TIHLMGRKLE KPNPEKNAWE HNSLTIPSPA CASEASLEVT 240
DLLLTALENP VKYAEDNMEQ KDTDRIICST NILHKTDQTL RRIVSQTMKE AKGNQEAFSE 300
MTFKQRWVRA NHAAIWRIIL GNEHIKCRSA KVGWLQCCRI EKRPLSTG 348 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0000049; F:tRNA binding; IEA:Compara.
 GO:0001514; P:selenocysteine incorporation; IEA:Compara.
 GO:0097056; P:selenocysteinyl-tRNA(Sec) biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR013641; Chromatin_KTI12.
 IPR020028; L-seryl-tRNA_Sec_kinase_euk.
 IPR027417; P-loop_NTPase. 
Pfam
 PF08433; KTI12 
SMART
  
PROSITE
  
PRINTS