Tag | Content |
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CPLM ID | CPLM-011737 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Puromycin-sensitive aminopeptidase |
Protein Synonyms/Alias | PSA; Cytosol alanyl aminopeptidase; AAP-S |
Gene Name | Npepps |
Gene Synonyms/Alias | Psa |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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156 | FVGELNDKMKGFYRS | ubiquitination | [1] | 209 | DISLVVPKDRVALSN | ubiquitination | [1] | 262 | DFVETRSKDGVCVRV | ubiquitination | [1] | 275 | RVYTPVGKAEQGKFA | ubiquitination | [1] | 468 | GMNMYLTKFQQKNAA | ubiquitination | [1] | 564 | KLKILMDKPEMSVVL | ubiquitination | [1] | 575 | SVVLKNVKPDQWVKL | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. |
Sequence Annotation | REGION 317 321 Substrate binding (By similarity). MOTIF 727 731 Nuclear localization signal (Potential). ACT_SITE 354 354 Proton acceptor (By similarity). METAL 353 353 Zinc; catalytic (By similarity). METAL 357 357 Zinc; catalytic (By similarity). METAL 376 376 Zinc; catalytic (By similarity). BINDING 181 181 Substrate (By similarity). MOD_RES 465 465 Nitrated tyrosine. |
Keyword | Aminopeptidase; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Metalloprotease; Nitration; Nucleus; Protease; Reference proteome; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 920 AA |
Protein Sequence | MWLAAAVPSL ARRLLLLGPP PPPLLLLLSR SSRRRRRLHS LGLAAMPEKR PFERLPAEVS 60 PINYSLCLKP DLLDFTFEGK LEAAAQVRQA TNQIVMNCAD IDIITASYAP EGDEEIHATG 120 FNYQNEDEKV TLSFPSTLQT GTGTLKIDFV GELNDKMKGF YRSRYTTPAG EVRYAAVTQF 180 EATDARRAFP CWDEPAIKAT FDISLVVPKD RVALSNMNVI DRKPYPDDEN LVEVKFARTP 240 VMSTYLVAFV VGEYDFVETR SKDGVCVRVY TPVGKAEQGK FALEVAAKTL PFYKDYFNVP 300 YPLPKIDLIA IADFAAGAME NWGLVTYRET ALLIDPKNSC SSSRQWVALV VGHELAHQWF 360 GNLVTMEWWT HLWLNEGFAS WIEYLCVDHC FPEYDIWTQF VSADYTRAQE LDALDNSHPI 420 EVSVGHPSEV DEIFDAISYS KGASVIRMLH DYIGDKDFKK GMNMYLTKFQ QKNAATEDLW 480 ESLESASGKP IAAVMNTWTK QMGFPLIYVE AEQVEDDRVL KLSQKKFCAS GPYGGEDCPQ 540 WMVPITISTS EDPNQAKLKI LMDKPEMSVV LKNVKPDQWV KLNLGTVGFY RTQYSSAMLE 600 SLLPGIRDLS LPPVDRLGLQ NDLFSLARAG IISTVEVLKV MEAFVNEPNY TVWSDLSCNL 660 GILSTLLSHT DFYEEIQEFV KDVFSPIGER LGWDPKPGEG HLDALLRGLV LGKLGKAGHK 720 ATLEEARRRF KEHVEGKQIL SADLRSPVYL TVLKHGDGAT LDIMLKLHKQ ADMQEEKNRI 780 ERVLGATLSP ELIQKVLTFA LSEEVRPQDT VSVIGGVAGG SKHGRKAAWK FIKDNWEELH 840 NRYQGGFLIS RLIKLSVEGF AVDKMAGEVK AFFESHPAPS AERTIQQCCE NILLNAAWLK 900 RDADSIHQYL LQRKTSPPSV 920 |
Gene Ontology | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW. GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0071456; P:cellular response to hypoxia; IEA:Compara. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
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