CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021857
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 4-trimethylaminobutyraldehyde dehydrogenase 
Protein Synonyms/Alias
 TMABADH; Aldehyde dehydrogenase family 9 member A1 
Gene Name
 Aldh9a1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
30VDASGTEKAFEPATGacetylation[1]
44GREIATFKCSGEKEVacetylation[1]
49TFKCSGEKEVNLAVEacetylation[1]
59NLAVENAKAAFKIWSacetylation[1]
63ENAKAAFKIWSKKSGacetylation[1]
67AAFKIWSKKSGLERCacetylation[1]
239GSVPTGMKIMEMAAKacetylation[1]
246KIMEMAAKGIKPITLacetylation[1]
249EMAAKGIKPITLELGacetylation[1]
298GTRVFVQKEIADAFTacetylation[1]
306EIADAFTKEVVRQTQacetylation[1]
316VRQTQRIKIGDPLLEacetylation[1]
462LPFGGYKKSGFGRENacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. 
Sequence Annotation
 NP_BIND 232 237 NAD (By similarity).
 ACT_SITE 254 254 Potential.
 ACT_SITE 288 288 Potential.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 298 298 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; NAD; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 494 AA 
Protein Sequence
MSTGTFVVSQ PLNYRGGARV EPVDASGTEK AFEPATGREI ATFKCSGEKE VNLAVENAKA 60
AFKIWSKKSG LERCQVLLEA ARIIKERRDE IAIMETINNG KSIFEARLDV DTSWQCLEYY 120
AGLAASMAGE HIQLPGGSFG YTRREPLGVC LGIGAWNYPF QIACWKSAPA LACGNAMIFK 180
PSPFTPVSAL LLAEIYTKAG APNGLFNVVQ GGAATGQFLC QHRDVAKVSF TGSVPTGMKI 240
MEMAAKGIKP ITLELGGKSP LIIFSDCNMK NAVKGALLAN FLTQGQVCCN GTRVFVQKEI 300
ADAFTKEVVR QTQRIKIGDP LLEDTRMGPL INAPHLERVL GFVRSAKEQG ATVLCGGEPY 360
APEDPKLKHG YYMTPCILTN CTDDMTCVKE EIFGPVMSIL TFETEAEVLE RANDTTFGLA 420
AGVFTRDIQR AHRVAAELQA GTCYINNYNV SPVELPFGGY KKSGFGRENG RVTIEYYSQL 480
KTVCVEMGDV ESAF 494 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0047105; F:4-trimethylammoniobutyraldehyde dehydrogenase activity; IDA:RGD.
 GO:0043176; F:amine binding; IDA:RGD.
 GO:0019145; F:aminobutyraldehyde dehydrogenase activity; IDA:RGD.
 GO:0051287; F:NAD binding; IDA:RGD.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0045329; P:carnitine biosynthetic process; TAS:RGD.
 GO:0001822; P:kidney development; IEP:RGD.
 GO:0001889; P:liver development; IEP:RGD. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS