CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036995
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 WD repeat-containing protein 67 
Protein Synonyms/Alias
  
Gene Name
 WDR67 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
152RIIQMPTKVRAIRHLubiquitination[1, 2]
577PVFNQYPKFIVDYQTubiquitination[3]
610TVEDMQAKVDQQRVEubiquitination[4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 961 AA 
Protein Sequence
MFLTYMETVT KELVSWMRGH ESSVFSISVH ASGKYAITTS SDTAQLWDLD TFQRKRKLNI 60
RQSVGIQKVF FLPLSNTILS CFKDNSIFAW ECDTLFCKYQ LPAPPESSSI LYKVFAVTRD 120
GRILAAGGKS NHLHLWCLEA RQLFRIIQMP TKVRAIRHLE FLPDSFDAGS NQVLGVLSQD 180
GIMRFINMQT CKLLFEIGSL DEGISSSAIS PHGRYIASIM ENGSLNIYSV QALTQEINKP 240
PPPLVKVIED LPKNKLSSSD LKMKVTSGRV QQPAKSRESK MQTRILKQDL TGDFESKKNE 300
LPDGLNKKRL QILLKGYGEY PTKYRMFIWR SLLQLPENHT AFSTLIDKGT HVAFLNLQKK 360
YPIKSRKLLR VLQRTLSALA HWSVIFSDTP YLPLLAFPFV KLFQNNQLIC FEVIATLIIN 420
WCQHWFEYFP NPPINILSMI ENVLAFHDKE LLQHFIDHDI TSQLYAWPLL ETVFSEVLTR 480
EEWLKLFDNI FSNHPSFLLM TVVAYNICSR TPLLSCNLKD DFEFFFHHRN NLDINVVIRQ 540
VYHLMETTPT DIHPDSMLNV FVALTKGQYP VFNQYPKFIV DYQTQERERI RNDELDYLRE 600
RQTVEDMQAK VDQQRVEDEA WYQKQELLRK AEETRREMLL QEEEKMIQQR QRLAAVKREL 660
KVKEMHLQDA ARRRFLKLQQ DQQEMELRRL DDEIGRKVYM RDREIAATAR DLEMRQLELE 720
SQKRLYEKNL TENQEALAKE MRADADAYRR KVDLEEHMFH KLIEAGETQS QKTQKVIKEN 780
LAKAEQACLN TDWQIQSLHK QKCDDLQRNK CYQEVAKLLR ENRRKEIEII NAMVEEEAKK 840
WKEAEGKEFR LRSAKKASAL SDASRKWFLK QEINAAVEHA ENPCHKEEPR FQNEQDSSCL 900
PRTSQLNDSS EMDPSTQISL NRRAVEWDTT GQNLIKKVRN LRQRLTARAR HRCQTPHLLA 960
A 961 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 
Interpro
 IPR000195; Rab-GTPase-TBC_dom.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00566; RabGAP-TBC
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS50086; TBC_RABGAP
 PS00678; WD_REPEATS_1
 PS50294; WD_REPEATS_REGION 
PRINTS