Tag | Content |
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CPLM ID | CPLM-000154 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 |
Protein Synonyms/Alias | DDAH-1; Dimethylarginine dimethylaminohydrolase 1; DDAHI; Dimethylargininase-1 |
Gene Name | Ddah1 |
Gene Synonyms/Alias | Ddah |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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100 | PGAPSRRKEVDMMKE | acetylation | [1] | 106 | RKEVDMMKEALEKLQ | acetylation | [1] | 144 | EFFVGLSKRTNQRGA | acetylation | [1] | 199 | ESAQKALKIMQQMSD | acetylation | [1] | 247 | EEYPESAKVYEKLKD | acetylation | [1] | 251 | ESAKVYEKLKDHLLI | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. |
Sequence Annotation | ACT_SITE 173 173 Proton donor (By similarity). ACT_SITE 274 274 Nucleophile (By similarity). METAL 274 274 Zinc (By similarity). BINDING 30 30 Substrate; via carbonyl oxygen (By BINDING 73 73 Substrate (By similarity). BINDING 78 78 Substrate (By similarity). BINDING 79 79 Substrate (By similarity). BINDING 98 98 Substrate (By similarity). BINDING 145 145 Substrate (By similarity). BINDING 268 268 Substrate; via carbonyl oxygen (By MOD_RES 2 2 N-acetylalanine. |
Keyword | Acetylation; Complete proteome; Direct protein sequencing; Hydrolase; Metal-binding; Reference proteome; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 285 AA |
Protein Sequence | MAGLSHPSVF GRATHAVVRA PPESLCRHAL RRSQGEEVDF ARAERQHQLY VGVLGSKLGL 60 QVVQLPADES LPDCVFVEDV AVVCEETALI TRPGAPSRRK EVDMMKEALE KLQLNIVEMK 120 DENATLDGGD VLFTGREFFV GLSKRTNQRG AEILADTFKD YAVSTVPVAD SLHLKSFCSM 180 AGPNLIAIGS SESAQKALKI MQQMSDHRYD KLTVPDDMAA NCIYLNIPSK GHVLLHRTPE 240 EYPESAKVYE KLKDHLLIPV SNSEMEKVDG LLTCCSVFIN KKTDS 285 |
Gene Ontology | GO:0005739; C:mitochondrion; IEA:Compara. GO:0016597; F:amino acid binding; IDA:RGD. GO:0016403; F:dimethylargininase activity; ISS:UniProtKB. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0006525; P:arginine metabolic process; IDA:RGD. GO:0000052; P:citrulline metabolic process; ISS:UniProtKB. GO:0045766; P:positive regulation of angiogenesis; IMP:RGD. GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IMP:RGD. GO:0003073; P:regulation of systemic arterial blood pressure; IEA:Compara. |
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