CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041578
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glutamate receptor ionotropic, NMDA 2B 
Protein Synonyms/Alias
 Glutamate receptor, ionotropic, N-methyl D-aspartate 2B, isoform CRA_a 
Gene Name
 Grin2b 
Gene Synonyms/Alias
 rCG_29810 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1021QPRSISKKPLDIGLPubiquitination[1]
1031DIGLPSSKHSQLSDLubiquitination[1]
1041QLSDLYGKFSFKSDRubiquitination[1]
1126HKRYFRDKEGLRDFYubiquitination[1]
1426FRALVTNKPVVSALHacetylation[2]
1426FRALVTNKPVVSALHubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Cell junction; Cell membrane; Complete proteome; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor; Reference proteome; Synapse; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1482 AA 
Protein Sequence
MKPSAECCSP KFWLVLAVLA VSGSKARSQK SPPSIGIAVI LVGTSDEVAI KDAHEKDDFH 60
HLSVVPRVEL VAMNETDPKS IITRICDLMS DRKIQGVVFA DDTDQEAIAQ ILDFISAQTL 120
TPILGIHGGS SMIMADKDES SMFFQFGPSI EQQASVMLNI MEEYDWYIFS IVTTYFPGYQ 180
DFVNKIRSTI ENSFVGWELE EVLLLDMSLD DGDSKIQNQL KKLQSPIILL YCTKEEATYI 240
FEVANSVGLT GYGYTWIVPS LVAGDTDTVP SEFPTGLISV SYDEWDYGLP ARVRDGIAII 300
TTAASDMLSE HSFIPEPKSS CYNTHEKRIY QSNMLNRYLI NVTFEGRNLS FSEDGYQMHP 360
KLVIILLNKE RKWERVGKWK DKSLQMKYYV WPRMCPETEE QEDDHLSIVT LEEAPFVIVE 420
SVDPLSGTCM RNTVPCQKRI ISENKTDEEP GYIKKCCKGF CIDILKKISK SVKFTYDLYL 480
VTNGKHGKKI NGTWNGMIGE VVMKRAYMAV GSLTINEERS EVVDFSVPFI ETGISVMVSR 540
SNGTVSPSAF LEPFSADVWV MMFVMLLIVS AVAVFVFEYF SPVGYNRCLA DGREPGGPSF 600
TIGKAIWLLW GLVFNNSVPV QNPKGTTSKI MVSVWAFFAV IFLASYTANL AAFMIQEEYV 660
DQVSGLSDKK FQRPNDFSPP FRFGTVPNGS TERNIRNNYA EMHAYMGKFN QRGVDDALLS 720
LKTGKLDAFI YDAAVLNYMA GRDEGCKLVT IGSGKVFAST GYGIAIQKDS GWKRQVDLAI 780
LQLFGDGEME ELEALWLTGI CHNEKNEVMS SQLDIDNMAG VFYMLGAAMA LSLITFICEH 840
LFYWQFRHCF MGVCSGKPGM VFSISRGIYS CIHGVAIEER QSVMNSPTAT MNNTHSNILR 900
LLRTAKNMAN LSGVNGSPQS ALDFIRRESS VYDISEHRRS FTHSDCKSYN NPPCEENLFS 960
DYISEVERTF GNLQLKDSNV YQDHYHHHHR PHSIGSTSSI DGLYDCDNPP FTTQPRSISK 1020
KPLDIGLPSS KHSQLSDLYG KFSFKSDRYS GHDDLIRSDV SDISTHTVTY GNIEGNAAKR 1080
RKQQYKDSLK KRPASAKSRR EFDEIELAYR RRPPRSPDHK RYFRDKEGLR DFYLDQFRTK 1140
ENSPHWEHVD LTDIYKERSD DFKRDSVSGG GPCTNRSHLK HGTGEKHGVV GGVPAPWEKN 1200
LTNVDWEDRS GGNFCRSCPS KLHNYSSTVA GQNSGRQACI RCEACKKAGN LYDISEDNSL 1260
QELDQPAAPV AVTSNASSTK YPQSPTNSKA QKKNRNKLRR QHSYDTFVDL QKEEAALAPR 1320
SVSLKDKGRF MDGSPYAHMF EMPAGESSFA NKSSVPTAGH HHNNPGSGYM LSKSLYPDRV 1380
TQNPFIPTFG DDQCLLHGSK SYFFRQPTVA GASKTRPDFR ALVTNKPVVS ALHGAVPGRF 1440
QKDICIGNQS NPCVPNNKNP RAFNGSSNGH VYEKLSSIES DV 1482 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0017146; C:N-methyl-D-aspartate selective glutamate receptor complex; IEA:Compara.
 GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0005262; F:calcium channel activity; IEA:Compara.
 GO:0005234; F:extracellular-glutamate-gated ion channel activity; IEA:InterPro.
 GO:0016594; F:glycine binding; IEA:Compara.
 GO:0004972; F:N-methyl-D-aspartate selective glutamate receptor activity; IEA:Compara.
 GO:0001662; P:behavioral fear response; IEA:Compara.
 GO:0048266; P:behavioral response to pain; IEA:Compara.
 GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0035235; P:ionotropic glutamate receptor signaling pathway; IEA:GOC.
 GO:0007612; P:learning; IEA:Compara.
 GO:0007613; P:memory; IEA:Compara.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Compara.
 GO:0048167; P:regulation of synaptic plasticity; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0007423; P:sensory organ development; IEA:Compara.
 GO:0001964; P:startle response; IEA:Compara.
 GO:0001967; P:suckling behavior; IEA:Compara. 
Interpro
 IPR001828; ANF_lig-bd_rcpt.
 IPR019594; Glu_rcpt_Glu/Gly-bd.
 IPR001320; Iontro_glu_rcpt.
 IPR001508; NMDA_rcpt.
 IPR018884; NMDAR2_C.
 IPR001638; SBP_bac_3. 
Pfam
 PF01094; ANF_receptor
 PF00060; Lig_chan
 PF10565; NMDAR2_C
 PF00497; SBP_bac_3 
SMART
 SM00918; Lig_chan-Glu_bd
 SM00079; PBPe 
PROSITE
  
PRINTS
 PR00177; NMDARECEPTOR.