CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043988
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 5-aminolevulinate synthase, nonspecific, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 ALAS1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
5***XRVPKYIFRHNDubiquitination[1]
136VRVADAAKNTEVCDEubiquitination[1, 2, 3]
199KQVGLELKPHSSAECubiquitination[1]
223EVMSEREKSYFSGLSubiquitination[1]
231SYFSGLSKLVSAQA*ubiquitination[1, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 237 AA 
Protein Sequence
XRVPKYIFRH NDVSHLRELL QRSDPSVPKI VAFETVHSMD GKAFGCVGGY IASTSSLIDT 60
VRSYAAGFIF TTSLPPMLLA GALESVRILK SAEGRVLRRQ HQRNVKLMRQ MLMDAGLPVV 120
HCPSHIIPVR VADAAKNTEV CDELMSRHNI YVQAINYPTV PRGEELLRIA PTPHHTPQMM 180
NYFLENLLVT WKQVGLELKP HSSAECNFCR RPLHFEVMSE REKSYFSGLS KLVSAQA 237 
Gene Ontology
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0009058; P:biosynthetic process; IEA:InterPro. 
Interpro
 IPR004839; Aminotransferase_I/II.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF00155; Aminotran_1_2 
SMART
  
PROSITE
  
PRINTS