UniProt Accession

 MMAD_HUMAN; Q9H3L0; B2R895; D3DP91; O95891 

Genbank Protein ID

 AF060224; AF131802; AF161510; AK313284; AC110782; CH471058; CH471058; CH471058; CH471058; BC000932; BC010894; BC022859; BC023995 

Genbank Nucleotide ID

 AAG43124.1; AAD20048.1; AAF29125.1; BAG36092.1; AAY14891.1; EAX11533.1; EAX11534.1; EAX11535.1; EAX11537.1; AAH00932.1; AAH10894.1; AAH22859.1; AAH23995.1 

Protein Name

 Methylmalonic aciduria and homocystinuria type D protein, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 MMADHC 

Gene Synonyms/Alias

 C2orf25; CL25022; HSPC161; My011 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
203	EREVLLEKFINGAKE	acetylation	[1, 2, 3, 4]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Involved in cobalamin metabolism. 

Sequence Annotation

 MOD_RES 203 203 N6-acetyllysine.  

Keyword

 Acetylation; Complete proteome; Disease mutation; Mitochondrion; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 296 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0009235; P:cobalamin metabolic process; IEA:InterPro. 

Interpro

 IPR019362; MMADHC. 

Pfam

 PF10229; DUF2246 

SMART

  

PROSITE

  

PRINTS