UniProt Accession

 G4P1_YEAST; P46672; D6VU41 

Genbank Protein ID

 U31348; X97644; Z72627; X95481; AY558498; BK006941 

Genbank Nucleotide ID

 AAC49072.1; CAA66247.1; CAA96812.1; CAA64750.1; AAS56824.1; DAA08002.1 

Protein Name

 GU4 nucleic-binding protein 1 

Protein Synonyms/Alias

 G4p1 protein; P42; Protein ARC1 

Gene Name

 ARC1 

Gene Synonyms/Alias

 G4P1; YGL105W; G3085 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
15	FESLIISKYPVSFTK	acetylation	[1]
132	LPHEVIEKKKKAPAG	acetylation	[1]
147	GAADAAAKADEDVSK	ubiquitination	[2]
218	FRVGFIQKAIKHPDA	acetylation	[1]
221	GFIQKAIKHPDADSL	acetylation	[1]
250	TVCSGLVKHFPLDAM	acetylation	[1]
269	VVVVCNLKPVNMRGI	acetylation	[1]
318	FGDEAPMKQLNPKKK	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Binds specifically G4 quadruplex nucleic acid structures (these are four-stranded right-handed helices, stabilized by guanine base quartets). Binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases. 

Sequence Annotation

 DOMAIN 205 307 tRNA-binding.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; DNA-binding; Reference proteome; RNA-binding; tRNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 376 AA 

Protein Sequence

Gene Ontology

 GO:0017102; C:methionyl glutamyl tRNA synthetase complex; IMP:SGD.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008047; F:enzyme activator activity; IDA:SGD.
 GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IDA:SGD.
 GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:SGD.
 GO:0000049; F:tRNA binding; IMP:SGD.
 GO:0051351; P:positive regulation of ligase activity; IDA:SGD.
 GO:0006418; P:tRNA aminoacylation for protein translation; IMP:SGD. 

Interpro

 IPR012340; NA-bd_OB-fold.
 IPR002547; tRNA-bd_dom. 

Pfam

 PF01588; tRNA_bind 

SMART

  

PROSITE

 PS50886; TRBD 

PRINTS