CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030608
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Small nuclear ribonucleoprotein-associated protein 
Protein Synonyms/Alias
  
Gene Name
 SNRPN 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
9MDSQTVGKSSKMLQHmethylation[1]
9MDSQTVGKSSKMLQHubiquitination[2]
12QTVGKSSKMLQHIDYacetylation[3]
12QTVGKSSKMLQHIDYmethylation[1]
12QTVGKSSKMLQHIDYubiquitination[2, 3, 4, 5]
36RIFIGTFKAFDKHMNacetylation[3]
36RIFIGTFKAFDKHMNubiquitination[2, 3, 4, 5]
40GTFKAFDKHMNLILCacetylation[6]
40GTFKAFDKHMNLILCubiquitination[3, 5, 7]
92TVEGPPPKDTGIARVubiquitination[2, 3, 4, 5]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [7] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding; Viral nucleoprotein; Virion. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 244 AA 
Protein Sequence
MMDSQTVGKS SKMLQHIDYR MRCILQDGRI FIGTFKAFDK HMNLILCDCD EFRKIKPKNA 60
KQPEREEKRV LGLVLLRGEN LVSMTVEGPP PKDTGIARVP LAGAAGGPGV GRAAGRGVPA 120
GVPIPQAPAG LAGPVRGVGG PSQQVMTPQG RGTVAAAAVA ATASIAGAPT QYPPGRGTPP 180
PPVGRATPPP GIMAPPPGMR PPMGPPIGLP PARGTPIGMP PPGMRPPPPG IRGPPPPGMR 240
PPRP 244 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW. 
Interpro
 IPR010920; LSM_dom.
 IPR001163; Ribonucl_LSM.
 IPR006649; Ribonucl_LSM_euk/arc.
 IPR017131; snRNP-assoc_SmB/SmN. 
Pfam
 PF01423; LSM 
SMART
 SM00651; Sm 
PROSITE
  
PRINTS