UniProt Accession

 C9JZ54_HUMAN; C9JZ54 

Genbank Protein ID

 AC006583; AC011816 

Genbank Nucleotide ID

  

Protein Name

 DNA mismatch repair protein Mlh1 

Protein Synonyms/Alias

  

Gene Name

 MLH1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
38	SYSDGKLKAPPKPCA	ubiquitination	[1, 2]
42	GKLKAPPKPCAGNQG	ubiquitination	[1]
66	YNIATRRKALKNPSE	ubiquitination	[2]
69	ATRRKALKNPSEEYG	ubiquitination	[2]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 83 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0030983; F:mismatched DNA binding; IEA:InterPro.
 GO:0006298; P:mismatch repair; IEA:InterPro. 

Interpro

 IPR002099; DNA_mismatch_repair.
 IPR011186; DNA_mismatch_repair_MLH1.
 IPR003594; HATPase_ATP-bd. 

Pfam

  

SMART

  

PROSITE

  

PRINTS