UniProt Accession

 MPC2_HUMAN; O95563; A8K261; Q3SXR6; Q6FIF3 

Genbank Protein ID

 AL035304; AL110297; AK290126; CR407632; CR533473; Z97876; CH471067; BC104157; BC104158 

Genbank Nucleotide ID

 CAA22909.1; CAB53738.1; BAF82815.1; CAG28560.1; CAG38504.1; CAI20075.1; EAW90814.1; AAI04158.1; AAI04159.1 

Protein Name

 Mitochondrial pyruvate carrier 2 

Protein Synonyms/Alias

 Brain protein 44 

Gene Name

 MPC2 

Gene Synonyms/Alias

 BRP44 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
27	VELMLPEKLRPLYNH	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Mediates the uptake of pyruvate into mitochondria. 

Sequence Annotation

 MOD_RES 19 19 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 127 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:LIFEdb.
 GO:0050833; F:pyruvate transmembrane transporter activity; IEA:Compara.
 GO:0006850; P:mitochondrial pyruvate transport; IEA:Compara.
 GO:0006090; P:pyruvate metabolic process; TAS:Reactome. 

Interpro

 IPR005336; UPF0041. 

Pfam

 PF03650; UPF0041 

SMART

  

PROSITE

  

PRINTS