Tag | Content |
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CPLM ID | CPLM-022627 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Plectin |
Protein Synonyms/Alias | PCN; PLTN; Plectin-1; Plectin-6 |
Gene Name | Plec |
Gene Synonyms/Alias | Plec1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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1307 | EIERHGEKVEECQKF | acetylation | [1] |
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Reference | [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ. Mol Cell. 2013 Jan 10;49(1):186-99. [ PMID: 23201123] |
Functional Description | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics. |
Sequence Annotation | DOMAIN 181 411 Actin-binding. DOMAIN 185 293 CH 1. DOMAIN 306 408 CH 2. REPEAT 653 727 Spectrin 1. REPEAT 748 832 Spectrin 2. REPEAT 845 938 Spectrin 3. REPEAT 1323 1423 Spectrin 4. REPEAT 2795 2832 Plectin 1. REPEAT 2833 2870 Plectin 2. REPEAT 2871 2908 Plectin 3. REPEAT 2909 2946 Plectin 4. REPEAT 2947 2984 Plectin 5. REPEAT 2988 3022 Plectin 6. REPEAT 3123 3160 Plectin 7. REPEAT 3161 3198 Plectin 8. REPEAT 3199 3236 Plectin 9. REPEAT 3237 3274 Plectin 10. REPEAT 3275 3312 Plectin 11. REPEAT 3315 3350 Plectin 12. REPEAT 3492 3529 Plectin 13. REPEAT 3530 3567 Plectin 14. REPEAT 3568 3605 Plectin 15. REPEAT 3606 3643 Plectin 16. REPEAT 3647 3681 Plectin 17. REPEAT 3827 3864 Plectin 18. REPEAT 3865 3902 Plectin 19. REPEAT 3903 3940 Plectin 20. REPEAT 3941 3978 Plectin 21. REPEAT 3982 4015 Plectin 22. REPEAT 4070 4107 Plectin 23. REPEAT 4108 4145 Plectin 24. REPEAT 4146 4183 Plectin 25. REPEAT 4184 4221 Plectin 26. REPEAT 4225 4259 Plectin 27. REPEAT 4272 4312 Plectin 28. REPEAT 4415 4452 Plectin 29. REPEAT 4453 4490 Plectin 30. REPEAT 4491 4528 Plectin 31. REPEAT 4529 4566 Plectin 32. REPEAT 4567 4604 Plectin 33. REGION 1 1478 Globular 1 (By similarity). REGION 1479 2762 Central fibrous rod domain (By REGION 2763 4691 Globular 2 (By similarity). REGION 4257 4307 Binding to intermediate filaments (By REGION 4632 4647 4 X 4 AA tandem repeats of G-S-R-X. MOD_RES 212 212 Phosphoserine. MOD_RES 728 728 Phosphoserine. MOD_RES 823 823 Phosphothreonine. MOD_RES 1443 1443 Phosphoserine. MOD_RES 1729 1729 Phosphoserine. MOD_RES 2788 2788 Phosphotyrosine. MOD_RES 3040 3040 Phosphotyrosine. MOD_RES 3098 3098 N6-acetyllysine (By similarity). MOD_RES 3369 3369 Phosphotyrosine. MOD_RES 3427 3427 N6-acetyllysine (By similarity). MOD_RES 3797 3797 Phosphotyrosine. MOD_RES 4037 4037 Phosphothreonine (By similarity). MOD_RES 4389 4389 Phosphoserine. MOD_RES 4391 4391 Phosphoserine. MOD_RES 4392 4392 Phosphoserine (By similarity). MOD_RES 4393 4393 Phosphoserine. MOD_RES 4396 4396 Phosphoserine. MOD_RES 4397 4397 Phosphoserine. MOD_RES 4398 4398 Phosphoserine (By similarity). MOD_RES 4399 4399 Phosphoserine. MOD_RES 4403 4403 Phosphoserine (By similarity). MOD_RES 4418 4418 Phosphothreonine (By similarity). MOD_RES 4546 4546 Phosphothreonine; by CDK1 (By MOD_RES 4620 4620 Phosphoserine (By similarity). MOD_RES 4622 4622 Phosphotyrosine. MOD_RES 4625 4625 Phosphoserine (By similarity). MOD_RES 4629 4629 Phosphoserine. MOD_RES 4633 4633 Phosphoserine. MOD_RES 4649 4649 Phosphoserine (By similarity). |
Keyword | 3D-structure; Acetylation; Actin-binding; Alternative splicing; Cell junction; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 4691 AA |
Protein Sequence | MSGEDSEVRP VAVAEGSSNG SSGSPSPGDT LPWNLGKTQR SRRSGGGSVG NGSVLDPAER 60 AVIRIADERD RVQKKTFTKW VNKHLIKHWR AEAQRHISDL YEDLRDGHNL ISLLEVLSGD 120 SLPRERDVIR SVRLPREKGR MRFHKLQNVQ IALDYLRHRQ VKLVNIRNDD IADGNPKLTL 180 GLIWTIILHF QISDIQVSGQ SEDMTAKEKL LLWSQRMVEG YQGLRCDNFT TSWRDGRLFN 240 AIIHRHKPML IDMNKVYRQT NLENLDQAFS VAERDLGVTR LLDPEDVDVP QPDEKSIITY 300 VSSLYDAMPR VPGAQDGVRA NELQLRWQEY RELVLLLLQW IRHHTAAFEE RKFPSSFEEI 360 EILWCQFLKF KETELPAKEA DKNRSKVIYQ SLEGAVQAGQ LKIPPGYHPL DVEKEWGKLH 420 VAILEREKQL RSEFERLECL QRIVSKLQME AGLCEEQLNQ ADALLQSDIR LLASGKVAQR 480 AGEVERDLDK ADGMIRLLFN DVQTLKDGRH PQGEQMYRRV YRLHERLVAI RTEYNLRLKA 540 GVGAPVTQVT LQSTQRRPEL EDSTLRYLQD LLAWVEENQR RIDSAEWGVD LPSVEAQLGS 600 HRGMHQSIEE FRAKIERARN DESQLSPATR GAYRDCLGRL DLQYAKLLNS SKARLRSLES 660 LHGFVAAATK ELMWLNEKEE EEVGFDWSDR NTNMAAKKES YSALMRELEM KEKKIKEIQN 720 TGDRLLREDH PARPTVESFQ AALQTQWSWM LQLCCCIEAH LKENTAYFQF FSDVREAEEQ 780 LQKLQETLRR KYSCDRTITV TRLEDLLQDA QDEKEQLNEY KGHLSGLAKR AKAIVQLKPR 840 NPAHPVRGHV PLIAVCDYKQ VEVTVHKGDQ CQLVGPAQPS HWKVLSGSSS EAAVPSVCFL 900 VPPPNQEAQE AVARLEAQHQ ALVTLWHQLH VDMKSLLAWQ SLSRDIQLIR SWSLVTFRTL 960 KPEEQRQALR NLELHYQAFL RDSQDAGGFG PEDRLVAERE YGSCSRHYQQ LLQSLEQGEQ 1020 EESRCQRCIS ELKDIRLQLE ACETRTVHRL RLPLDKDPAR ECAQRIAEQQ KAQAEVEGLG 1080 KGVARLSAEA EKVLALPEPS PAAPTLRSEL ELTLGKLEQV RSLSAIYLEK LKTISLVIRS 1140 TQGAEEVLKT HEEQLKEAQA VPATLQELEA TKASLKKLRA QAEAQQPVFN TLRDELRGAQ 1200 EVGERLQQRH GERDVEVERW RERVTQLLER WQAVLAQTDV RQRELEQLGR QLRYYRESAD 1260 PLSAWLQDAK RRQEQIQAVP IANCQAAREQ LRQEKALLEE IERHGEKVEE CQKFAKQYIN 1320 AIKDYELQLI TYKAQLEPVA SPAKKPKVQS GSESVIQEYV DLRTRYSELT TLTSQYIKFI 1380 SETLRRMEEE ERLAEQQRAE ERERLAEVEA ALEKQRQLAE AHAQAKAQAE LEAQELQRRM 1440 QEEVARREEA AVDAQQQKRS IQEELQHLRQ SSEAEIQAKA QQVEAAERSR MRIEEEIRVV 1500 RLQLETTERQ RGGAEGELQA LRARAEEAEA QKRQAQEEAE RLRRQVQDES QRKRQAEAEL 1560 ALRVKAEAEA AREKQRALQA LDELRLQAEE AERRLRQAEA ERARQVQVAL ETAQRSAEVE 1620 LQSKRASFAE KTAQLERTLQ EEHVTVAQLR EEAERRAQQQ AEAERAREEA ERELERWQLK 1680 ANEALRLRLQ AEEVAQQKSL AQADAEKQKE EAEREARRRG KAEEQAVRQR ELAEQELEKQ 1740 RQLAEGTAQQ RLAAEQELIR LRAETEQGEQ QRQLLEEELA RLQHEATAAT QKRQELEAEL 1800 AKVRAEMEVL LASKARAEEE SRSTSEKSKQ RLEAEAGRFR ELAEEAARLR ALAEEAKRQR 1860 QLAEEDAARQ RAEAERVLTE KLAAISEATR LKTEAEIALK EKEAENERLR RLAEDEAFQR 1920 RRLEEQAALH KADIEERLAQ LRKASESELE RQKGLVEDTL RQRRQVEEEI MALKVSFEKA 1980 AAGKAELELE LGRIRSNAED TMRSKEQAEL EAARQRQLAA EEEQRRREAE ERVQRSLAAE 2040 EEAARQRKVA LEEVERLKAK VEEARRLRER AEQESARQLQ LAQEAAQKRL QAEEKAHAFV 2100 VQQREEELQQ TLQQEQNMLD RLRSEAEAAR RAAEEAEEAR EQAEREAAQS RKQVEEAERL 2160 KQSAEEQAQA QAQAQAAAEK LRKEAEQEAA RRAQAEQAAL KQKQAADAEM EKHKKFAEQT 2220 LRQKAQVEQE LTTLRLQLEE TDHQKSILDE ELQRLKAEVT EAARQRSQVE EELFSVRVQM 2280 EELGKLKARI EAENRALILR DKDNTQRFLE EEAEKMKQVA EEAARLSVAA QEAARLRQLA 2340 EEDLAQQRAL AEKMLKEKMQ AVQEATRLKA EAELLQQQKE LAQEQARRLQ EDKEQMAQQL 2400 VEETQGFQRT LEAERQRQLE MSAEAERLKL RMVEMSRAQA RAEEDAQRFR KQAEEIGEKL 2460 HRTELATQEK VTLVQTLEIQ RQQSDHDAER LREAIAELER EKEKLKQEAK LLQLKSEEMQ 2520 TVQQEQILQE TQALQKSFLS EKDSLLQRER FIEQEKAKLE QLFQDEVAKA KQLREEQQRQ 2580 QQQMEQEKQE LMASMEEARR RQREAEEGVR RKQEELQHLE QQRQQQEKLL AEENQRLRER 2640 LQRLEEEHRA ALAHSEIATT QAASTKALPN GRDAPDGPSV EAEPEYTFEG LRQKVPAQQL 2700 QEAGILSQEE LQRLAQGHTT VAELTQREDV YRYLKGRSSI AGLLLKPTNE KLSVYTALQR 2760 QLLSPGTALI LLEAQAASGF LLDPVRNRRL TVNEAVKEGV VGPELHHKLL SAERAVTGYK 2820 DPYTGEQISL FQAMKKDLIV RDHGVRLLEA QIATGGIIDP VHSHRVPVDV AYKRGYFDEE 2880 MNRILSDPSD DTKGFFDPNT HENLTYLQLL ERCVEDPETG LRLLPLTDKA AKGGELVYTD 2940 TEARDVFEKA TVSAPFGKFQ GRTVTIWEII NSEYFTAEQR RDLLQQFRTG HITVEKIIKI 3000 VITVVEEHER KGQLCFEGLR ALVPAAELLD SGVISHELYQ QLQRGERSVR EVAEADSVRQ 3060 ALRGTNVIAG VWLEEAGQKL SIYEALKKDL LQPEVAVALL EAQAGTGHII DPATSARLTV 3120 DEAVRAGLVG PELHEKLLSA EKAVTGYRDP YSGQSVSLFQ ALKKGLIPRE QGLRLLDAQL 3180 STGGIVDPSK SHRVPLDVAY ARGYLDKETN RALTSPRDDA RVYHDPSTQE PVTYSQLQQR 3240 CRSDQLTGLS LLPLSEKAVR ARQEEVYSEL QARETLEQAK VEVPVGSFKG RAMTVWELIS 3300 SEYFTEEQRQ ELLRQFRTGK VTVEKVIKIV ITIVEEVETR RQERLSFSGL RAPVPASELL 3360 DAKILSRAQF DQLKDGKTSV KELSEVGSVR TLLQGSGCLA GIYLEDSKEK VTIYEAMRRG 3420 LLRPSTATLL LEAQAATGFL VDPVRNQRLY VHEAVKAGVV GPELHEKLLS AEKAVTGYKD 3480 PYSGNTISLF QAMKKGLVLR DHAIRLLEAQ VATGGIIDPV HSHRLPVDVA YQRGYFDEEM 3540 NRVLADPSDD TKGFFDPNTH ENLTYLQLLE RCVEDPETGL RLLPLKGAEK TEVVETTQVY 3600 TEEETRRAFE ETQIDIPGGG SHGGSSMSLW EVMQSNMIPE DQRARLMADF QAGRVTKERM 3660 IIIIIEIIEK TEIIRQQNLA SYDYVRRRLT AEDLYEARII SLETYNLFRE GTKNLREVLE 3720 MESAWRYLYG TGAVAGVYLP GSRQTLTIYQ ALKKGLLSAE VARLLLEAQA ATGFLLDPVK 3780 GERLTVDEAV RKGLVGPELH DRLLSAERAV TGYRDPYTEQ TISLFQAMKK ELIPAEEALR 3840 LLDAQLATGG IVDPRLGFHL PLEVAYQRGY LNKDTHDQLS EPSEVRSYVD PSTDERLSYT 3900 QLLKRCRRDD PSGQMLLLLS DARKLTFRGL RKQITVEELV RSQVMDEATA LQLQEGLTSI 3960 EEVTKNLQKF LEGTSCIAGV FVDATKERLS VYQAMKKGII RPGTAFELLE AQAATGYVID 4020 PIKGLKLTVE EAVRMGIVGP EFKDKLLSAE RAVTGYKDPY SGKLISLFQA MKKGLILKDH 4080 GIRLLEAQIA TGGIIDPEES HRLPVEVAYK RGLFDEEMNE ILTDPSDDTK GFFDPNTEEN 4140 LTYLQLMERC ITDPQTGLCL LPLKEKKRER KTSSKSSVRK RRVVIVDPET GKEMSVYEAY 4200 RKGLIDHQTY LELSEQECEW EEITISSSDG VVKSMIIDRR SGRQYDIDDA ITKNLIDRSA 4260 LDQYRAGTLS ITEFADMLSG NAGGFRSRSS SVGSSSSYPI SSAGPRTQLA SWSDPTEETG 4320 PVAGILDTET LEKVSITEAM HRNLVDNITG QRLLEAQACT GGIIDPSTGE RFPVTEAVNK 4380 GLVDKIMVDR INLAQKAFCG FEDPRTKTKM SAAQALKKGW LYYEAGQRFL EVQYLTGGLI 4440 EPDTPGRVSL DEALQRGTVD ARTAQKLRDV SAYSKYLTCP KTKLKISYKD ALDRSMVEEG 4500 TGLRLLEAAA QSSKGYYSPY SVSGSGSTAG SRTGSRTGSR AGSRRGSFDA TGSGFSMTFS 4560 SSSYSSSGYG RRYASGPSAS LGGPESAVA 4589 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |