UniProt Accession

 C1D_HUMAN; Q13901; A8K336; D6W5F8; Q05D64 

Genbank Protein ID

 X95592; AK290451; AC079112; CH471053; CH471053; BC005235; BC009584; BC009589; BC016284 

Genbank Nucleotide ID

 CAA64845.1; BAF83140.1; AAX88887.1; EAW99884.1; EAW99885.1; AAH05235.1; AAH09584.1; AAH09589.1; AAH16284.1 

Protein Name

 Nuclear nucleic acid-binding protein C1D 

Protein Synonyms/Alias

 hC1D 

Gene Name

 C1D 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
46	SRNELLQKLDPLEQA	ubiquitination	[1]
119	GAASRFVKNALWEPK	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity). 

Sequence Annotation

 REGION 1 100 Required for transcriptional repression
 REGION 50 100 Interaction with NR1D1 (By similarity).
 REGION 100 141 Interaction with NCOR1 and NCOR2 (By  

Keyword

 Apoptosis; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; RNA-binding; rRNA processing; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 141 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0000176; C:nuclear exosome (RNase complex); TAS:UniProtKB.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0017053; C:transcriptional repressor complex; IEA:Compara.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0003723; F:RNA binding; IDA:UniProtKB.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0000460; P:maturation of 5.8S rRNA; IMP:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011082; Exosome-assoc_fac/DNA_repair.
 IPR007146; Sas10/Utp3/C1D. 

Pfam

 PF04000; Sas10_Utp3 

SMART

  

PROSITE

  

PRINTS