CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038223
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Versican core protein 
Protein Synonyms/Alias
  
Gene Name
 Vcan 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
520SLKELPEKNKTPYESacetylation[1]
522KELPEKNKTPYESTEacetylation[1]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; EGF-like domain; Reference proteome; Repeat; Sushi. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3354 AA 
Protein Sequence
MLINMKGILW MCSTLLLTHA LHQAKMETSP PVKGSLSGKV VLPCHFSTLP TLPPNYNTSE 60
FLRIKWSKME VDKNGKDIKE TTVLVAQNGN IKIGQDYKGR VSVPTHPDDV GDASLTMVKL 120
RASDAGVYRC DVMYGIEDTQ DTMSLAVDGV VFHYRAATSR YTLNFAAAQQ ACLDIGAVIA 180
SPEQLFAAYE DGFEQCDAGW LSDQTVRYPI RAPREGCYGD MMGKEGVRTY GFRSPQETYD 240
VYCYVDHLDG DVFHITAPSK FTFEEAEAEC TSRDARLATV GELQAAWRNG FDQCDYGWLS 300
DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTCFPLPDSR FDAYCFKPKQ NISEATTIEM 360
NILAETSSPS LSKEPHMVPD RATPVIPLAT ELPIFTTHFP PAGNIVNSEQ KSVVYSQAIT 420
GRLAMESPTT TRNTINSWDL NDSLASGSGP LGMPDISEIK EEELRSTTVI SQHATGSQAV 480
ITEDTQTHES VSQIEQIEVG PLVTSMEITN HISLKELPEK NKTPYESTEV TLEHTTEMPT 540
VSASPELATT SHYGFTLRED DREDRTLTVR SDQSTRVFSQ IPEVITVSKT SEDTTYSQLG 600
DLESISTSTI TMLGTDRSLI DKEKEPKTNG KVTEDEFGQS QPTTTFPSQH LTEVELLPYS 660
GDTTSVEGIS TVIYPSLQTD VTQGRERTET PRPELKKDPY TVDEIPEKVT KDPFIGKTEE 720
VFSGMPLSTS SSESSVERTE SVSPALTIEK LTVKPTEARD VEEMTTLTRL ETDVTKSDKD 780
VTRVHLTHST LNVEVVTVSK WPGDEDNSTS KPLPSTEHAG FTKLPPVPLS TIGINGKDKE 840
IPSFTDGGGE YTLFPDGTPK PLEKVSEEDL ASGELTVTFH TSTSIGSAEK SASGEPTTGD 900
RFLPTTSTED QVINATAEGS ALGEDIEASK PLFTGPPFVH TSDVEELAFV NYSSTQEPTT 960
YVDISHTSPL SIIPKTEWSV LETSVSLEDE ILGKSDQDIL EQTHLEATMS PGALRTTGVS 1020
QGETQEEPQT PGSPFPTFSS TAVMAKETTA FEEGEGSTYT PSEGRLMTGS ERVPGLETTP 1080
VGTSYPPGAI TDQEVEMDTM VTLMSTIRPT VVSSTEPEVI YEAEGSSPTE FASTLRPFQT 1140
HVTQLMEETT EEGKKASLDY TDLGSGLFEP RATELPKFPT TPSDISVFTA IDSLHRTPPL 1200
SPSSSFTEEQ RVFEEESSEK TTGDILPGES VTQHPVTTLI DIVAMKTESD IDHMTSKPPV 1260
TQPTRPSVVE RKTTSKTQEL STSTPAAGTK FHPDINVYII EVRENKTGRL SDMIVSGHPI 1320
DSESKEEEPC SEETDPLHDL FAEILPELPD SFEIDIYHSE EDEDGEEDCV NATDVTTTPS 1380
VQYINGKQLV TTVPKDPEAA EARRGQYESV APSQNFPDSS ATDTHQFILA ETESSTTMQF 1440
KKSKEGTELL EITWKPETYP ETPDHVSSGE PDVFPTLSSH DGKTTRWSES ITESSPNLEN 1500
PVHKQPKPVP LFPEESSGEG AIEQASQETI LSRATEVALG KETDQSPTLS TSSILSSSVS 1560
VNVLEEEPLT LTGISQTDES MSTIESWVEI TPSQTVKFSE SSSAPIIEGS GEVEENKNKI 1620
FNMVTDLPQR DPTDTLSPLD MSKIMITNHH IYIPATTAPL DSKLPSPDAR PTQFGIQTAT 1680
SEWVSDKSFE GRKREEDEEG AVNAAHQGEV RAATERSDHL LLTPELESSN VDASSDLATW 1740
EGFILETTPT ESEKEMANST PVFRETIGVA NVEAQPFEHS SSSHPRVQEE LTTLSGNPPS 1800
LFTDLGSGDA STGMELITAS LFTLDLESET KVKKELPSTP SPSVEISSSF EPTGLTPSTV 1860
LDIEIAGVMS QTSQKTLISE ISGKPTSQSG VRDLYTGFPM GEDFSGDFSE YPTVSYPTMK 1920
EETVGMGGSD DERVRDTQTS SSIPTTSDNI YPVPDSKGPD STVASTTAFP WEEVMSSAEG 1980
SGEQLASVRS SVGPVLPLAV DIFSGTESPY FDEEFEEVAA VTEANERPTV LPTAASGNTV 2040
DLTENGYIEV NSTMSLDFPQ TMEPSKLWSK PEVNLDKQEI GRETVTKEKA QGQKTFESLH 2100
SSFAPEQTIL ETQSLIETEF QTSDYSMLTT LKTYITNKEV EEEGMSIAHM STPGPGIKDL 2160
ESYTTHPEAP GKSHSFSATA LVTESGAARS VLMDSSTQEE ESIKLFQKGV KLTNKESNAD 2220
LSFSGLGSGE ALPPLPTTSV NLTDMKQIIS TLYAETSHME SLGTSILGDK MEDHERMEDV 2280
SNEVRMLISK TGSISQDSTE ALDTTLSHTG TEEPTTSTLP FVKLMDLERS PKQTLRWEEE 2340
TQTHRPQTMS GLISNENSSA SEAEEAATSP TAFLPQTYSV EMTKHFAPSE SQPSDLFNVN 2400
SGEGSGEVDT LDLVYTSGTT QASSQGDSML ASHGFLEKHP EVSKTEAGAT DVSPTASAMF 2460
LHHSEYKSSL YPTSTLPSTE PYKSPSEGIE DGLQDNIQFE GSTLKPSRRK TTESIIIDLD 2520
KEDSKDLGLT ITESAIVEIL PELTSDKNII IDIDHTKPVY EYIPGIQTDL DPEIKLESHG 2580
SSEESLQVQE KYEGAVTLSP TEESFEGSGD ALLAGYTQAI YNESVTPNDG KQAEDISFSF 2640
ATGIPVSSTE TELHTFFPTA STLHIPSKLT TASPEIDKPN IEAISLDDIF ESSTLSDGQA 2700
IADQSEVIST LGHLEKTQEE YEEKKYGGPS FQPEFFSGVG EVLTDPPAYV SIGSTYLIAQ 2760
TLTELPNVVR PSDSTHYTEA TPEVSSLAEL SPQIPSSPFP VYVDNGVSKF PEVPHTSAQP 2820
VSTVTSSQKS IESPFKEVHA NIEETIKPLG GNVHRTEPPS MSRDPALDVS EDESKHKLLE 2880
ELETSPTKPE TSQDFPNKAK DHIPGETVGM LAGIRTTESE PVITADDMEL GGATQQPHSA 2940
SAAFRVETGM VPQPIQQEPE RPTFPSLEIN HETHTSLFGE SILATSEKQV SQKILDNSNQ 3000
ATVSSTLDLH TAHALSPFSI LDNSNETAFL IGISEESVEG TAVYLPGPDL CKTNPCLNGG 3060
TCYPTETSYV CTCAPGYSGD QCELDFDECH SNPCRNGATC VDGFNTFRCL CLPSYVGALC 3120
EQDTETCDYG WHKFQGQCYK YFAHRRTWDA AERECRLQGA HLTSILSHEE QMFVNRVGHD 3180
YQWIGLNDKM FEHDFRWTDG SALQYENWRP NQPDSFFSAG EDCVVIIWHE NGQWNDVPCN 3240
YHLTYTCKKG TVACGQPPVV ENAKTFGKMK PRYEINSLIR YHCKDGFIQR HLPTIRCLGN 3300
GRWAMPKITC MNPSAYQRTY SKKYLKNSSS AKDNSINTSK HEHRWSRRRQ ETRR 3354 
Gene Ontology
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005578; C:proteinaceous extracellular matrix; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0005540; F:hyaluronic acid binding; IEA:InterPro.
 GO:0007155; P:cell adhesion; IEA:InterPro.
 GO:0008347; P:glial cell migration; IEA:Compara.
 GO:0007507; P:heart development; IMP:MGI. 
Interpro
 IPR001304; C-type_lectin.
 IPR016186; C-type_lectin-like.
 IPR018378; C-type_lectin_CS.
 IPR016187; C-type_lectin_fold.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set.
 IPR000538; Link.
 IPR000436; Sushi_SCR_CCP. 
Pfam
 PF00008; EGF
 PF00059; Lectin_C
 PF00084; Sushi
 PF07686; V-set
 PF00193; Xlink 
SMART
 SM00032; CCP
 SM00034; CLECT
 SM00181; EGF
 SM00179; EGF_CA
 SM00409; IG
 SM00445; LINK 
PROSITE
 PS00010; ASX_HYDROXYL
 PS00615; C_TYPE_LECTIN_1
 PS50041; C_TYPE_LECTIN_2
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS50835; IG_LIKE
 PS01241; LINK_1
 PS50963; LINK_2
 PS50923; SUSHI 
PRINTS
 PR01265; LINKMODULE.