CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004509
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cyclic AMP-dependent transcription factor ATF-2 
Protein Synonyms/Alias
 cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; MXBP protein; cAMP response element-binding protein CRE-BP1 
Gene Name
 Atf2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
391RNEVAQLKQLLLAHKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex. 
Sequence Annotation
 DOMAIN 334 397 bZIP.
 ZN_FING 7 31 C2H2-type.
 REGION 336 356 Basic motif (By similarity).
 REGION 362 390 Leucine-zipper (By similarity).
 MOD_RES 51 51 Phosphothreonine; by MAPK11 and MAPK14.
 MOD_RES 53 53 Phosphothreonine; by MAPK1, MAPK3,
 MOD_RES 72 72 Phosphoserine (By similarity).
 MOD_RES 94 94 Phosphoserine.
 MOD_RES 98 98 Phosphothreonine (By similarity).
 MOD_RES 310 310 Phosphoserine (By similarity).  
Keyword
 Activator; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 487 AA 
Protein Sequence
MSDDKPFLCT APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RNDSVIVADQ TPTPTRFLKN 60
CEEVGLFNEL ASPFENEFKK ASEDDIKKMP LDLSPLATPI IRSKIEEPSV VETTHQDSPL 120
PHPESTTSDE KEVPLAQTAQ PTSAIVRPAS LQVPNVLLTS SDSSVIIQQA VPSPTSSTVI 180
TQAPSSNRPI VPVPGPFPLL LHLPNGQTMP VAIPASITSS NVHVPAAVPL VRPVTMVPSV 240
PGIPGPSSPQ PVQSEAKMRL KAALTQQHPP VTNGDTVKGH GSGLVRTQSE ESRPQSLQQP 300
ATSTTETPAS PAHTTPQTQN TSGRRRRAAN EDPDEKRRKF LERNRAAASR CRQKRKVWVQ 360
SLEKKAEDLS SLNGQLQSEV TLLRNEVAQL KQLLLAHKDC PVTAMQKKSG YHTADKDDSS 420
EDLSVPSSPH TEAIQHSSVS TSNGVSSTSK AEAVATSVLT QMADQSTEPA LSQIVMAPPS 480
QAQPSGS 487 
Gene Ontology
 GO:0016020; C:membrane; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0035497; F:cAMP response element binding; IEA:Compara.
 GO:0008140; F:cAMP response element binding protein binding; IEA:Compara.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:MGI.
 GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0060612; P:adipose tissue development; IGI:MGI.
 GO:0045444; P:fat cell differentiation; IGI:MGI.
 GO:0003151; P:outflow tract morphogenesis; IMP:MGI.
 GO:0032915; P:positive regulation of transforming growth factor beta2 production; IMP:MGI.
 GO:0006970; P:response to osmotic stress; ISS:UniProtKB. 
Interpro
 IPR004827; bZIP.
 IPR016378; TF_cAMP-dep.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00170; bZIP_1 
SMART
 SM00338; BRLZ
 SM00355; ZnF_C2H2 
PROSITE
 PS50217; BZIP
 PS00036; BZIP_BASIC
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS