CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019648
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Centrosomal protein of 89 kDa 
Protein Synonyms/Alias
 Coiled-coil domain-containing protein 123 
Gene Name
 CEP89 
Gene Synonyms/Alias
 CCDC123 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
682QQEDFAGKTAQYRQEubiquitination[1, 2]
700LHQVLKDKQEVLDQAubiquitination[2, 3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. 
Sequence Annotation
 MOD_RES 50 50 Phosphoserine.  
Keyword
 Alternative splicing; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Mitochondrion; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 783 AA 
Protein Sequence
MLLGFRRGRR SHFKHIIHGL LPAASVAPKA AVPRTPPPRS PNPSPERPRS ALAAAILATT 60
LTGRTVAIPQ PRQRSRSESD VSSVEQDSFI EPYATTSQLR PRPNWQSEMG RRSSLPSFET 120
LDYGDEEDIE TQLSSSGKEL GDVSAREDRG GHSDDLYAVP HRNQVPLLHE VNSEDDENIS 180
HQDGFPGSPP APQRTQQKDG KHPVLNLKDE KPPLCEKPPP SPDITGRARQ RYTEITREKF 240
EALKEENMDL NNMNQSLTLE LNTMKQAMKE LQLKLKGMEK EKRKLKEAEK ASSQEVAAPE 300
LLYLRKQAQE LVDENDGLKM TVHRLNVELS RYQTKFRHLS KEESLNIEGL PSKGPIPPWL 360
LDIKYLSPLL LAYEDMMKEK DELNATLKEE MRMFRMRVQE VVKENEELHQ ELNKSSAVTS 420
EEWRQLQTQA KLVLEENKLL LEQLEIQQRK AKDSHQERLQ EVSKLTKQLM LLEAKTHGQE 480
KELAENREQL EILRAKCQEL KTHSDGKIAV EVHKSIVNEL KSQLQKEEEK ERAEMEELME 540
KLTVLQAQKK SLLLEKNSLT EQNKALEAEL ERAQKINRKS QKKIEVLKKQ VEKAMGNEMS 600
AHQYLANLVG LAENITQERD SLMCLAKCLE SEKDGVLNKV IKSNIRLGKL EEKVKGYKKQ 660
AALKLGDISH RLLEQQEDFA GKTAQYRQEM RHLHQVLKDK QEVLDQALQQ NREMEGELEV 720
IWESTFRENR RIRELLQDTL TRTGVQDNPR ALVAPSLNGV SQADLLDGCD VCSYDLKSHA 780
PTC 783 
Gene Ontology
 GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0000922; C:spindle pole; IDA:UniProtKB.
 GO:0030030; P:cell projection organization; IEA:UniProtKB-KW. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS