CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006559
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Low-density lipoprotein receptor 
Protein Synonyms/Alias
 LDL receptor 
Gene Name
 Ldlr 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
832FDNPVYQKTTEDELHubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. 
Sequence Annotation
 DOMAIN 25 65 LDL-receptor class A 1.
 DOMAIN 66 106 LDL-receptor class A 2.
 DOMAIN 107 145 LDL-receptor class A 3.
 DOMAIN 146 186 LDL-receptor class A 4.
 DOMAIN 196 234 LDL-receptor class A 5.
 DOMAIN 235 273 LDL-receptor class A 6.
 DOMAIN 275 314 LDL-receptor class A 7.
 DOMAIN 315 354 EGF-like 1.
 DOMAIN 355 394 EGF-like 2; calcium-binding (Potential).
 REPEAT 398 439 LDL-receptor class B 1.
 REPEAT 440 485 LDL-receptor class B 2.
 REPEAT 486 528 LDL-receptor class B 3.
 REPEAT 529 572 LDL-receptor class B 4.
 REPEAT 573 615 LDL-receptor class B 5.
 REPEAT 616 658 LDL-receptor class B 6.
 DOMAIN 663 713 EGF-like 3.
 REGION 722 770 Clustered O-linked oligosaccharides.
 REGION 813 862 Required for MYLIP-triggered down-
 MOTIF 825 830 NPXY motif.
 MOD_RES 718 718 Phosphothreonine (By similarity).
 MOD_RES 725 725 Phosphothreonine (By similarity).
 MOD_RES 733 733 Phosphothreonine (By similarity).
 MOD_RES 735 735 Phosphoserine (By similarity).
 CARBOHYD 97 97 N-linked (GlcNAc...) (Potential).
 CARBOHYD 273 273 N-linked (GlcNAc...) (Potential).
 CARBOHYD 462 462 N-linked (GlcNAc...) (Potential).
 DISULFID 34 52 By similarity.
 DISULFID 46 63 By similarity.
 DISULFID 68 82 By similarity.
 DISULFID 75 95 By similarity.
 DISULFID 89 104 By similarity.
 DISULFID 109 121 By similarity.
 DISULFID 116 134 By similarity.
 DISULFID 128 143 By similarity.
 DISULFID 148 160 By similarity.
 DISULFID 155 173 By similarity.
 DISULFID 167 184 By similarity.
 DISULFID 198 210 By similarity.
 DISULFID 205 223 By similarity.
 DISULFID 217 232 By similarity.
 DISULFID 237 249 By similarity.
 DISULFID 244 262 By similarity.
 DISULFID 256 271 By similarity.
 DISULFID 277 290 By similarity.
 DISULFID 285 303 By similarity.
 DISULFID 297 314 By similarity.
 DISULFID 319 330 By similarity.
 DISULFID 326 339 By similarity.
 DISULFID 341 353 By similarity.
 DISULFID 359 369 By similarity.
 DISULFID 365 378 By similarity.
 DISULFID 380 393 By similarity.
 DISULFID 667 682 By similarity.
 DISULFID 678 697 By similarity.
 DISULFID 699 712 By similarity.  
Keyword
 Cell membrane; Cholesterol metabolism; Coated pit; Complete proteome; Disulfide bond; EGF-like domain; Endocytosis; Endosome; Glycoprotein; Golgi apparatus; LDL; Lipid metabolism; Lipid transport; Lysosome; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Steroid metabolism; Sterol metabolism; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 862 AA 
Protein Sequence
MSTADLMRRW VIALLLAAAG VAAEDSCSRN EFQCRDGKCI ASKWVCDGSP ECPDGSDESP 60
ETCMSVTCQS NQFSCGGRVS RCIPDSWRCD GQVDCENDSD EQGCPPKTCS QDDFRCQDGK 120
CISPQFVCDG DRDCLDGSDE AHCQATTCGP AHFRCNSSIC IPSLWACDGD VDCVDGSDEW 180
PQNCQGRDTA SKGVSSPCSS LEFHCGSSEC IHRSWVCDGE ADCKDKSDEE HCAVATCRPD 240
EFQCADGSCI HGSRQCDREH DCKDMSDELG CVNVTQCDGP NKFKCHSGEC ISLDKVCDSA 300
RDCQDWSDEP IKECKTNECL DNNGGCSHIC KDLKIGSECL CPSGFRLVDL HRCEDIDECQ 360
EPDTCSQLCV NLEGSYKCEC QAGFHMDPHT RVCKAVGSIG YLLFTNRHEV RKMTLDRSEY 420
TSLLPNLKNV VALDTEVTNN RIYWSDLSQK KIYSALMDQA PNLSYDTIIS EDLHAPDGLA 480
VDWIHRNIYW TDSVPGSVSV ADTKGVKRRT LFQEAGSRPR AIVVDPVHGF MYWTDWGTPA 540
KIKKGGLNGV DIHSLVTENI QWPNGITLDL SSGRLYWVDS KLHSISSIDV NGGNRKTILE 600
DENRLAHPFS LAIYEDKVYW TDVINEAIFS ANRLTGSDVN LVAENLLSPE DIVLFHKVTQ 660
PRGVNWCETT ALLPNGGCQY LCLPAPQIGP HSPKFTCACP DGMLLAKDMR SCLTEVDTVL 720
TTQGTSAVRP VVTASATRPP KHSEDLSAPS TPRQPVDTPG LSTVASVTVS HQVQGDMAGR 780
GNEEQPHGMR FLSIFFPIAL VALLVLGAVL LWRNWRLKNI NSINFDNPVY QKTTEDELHI 840
CRSQDGYTYP SRQMVSLEDD VA 862 
Gene Ontology
 GO:0009986; C:cell surface; ISS:UniProtKB.
 GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.
 GO:0005769; C:early endosome; ISS:UniProtKB.
 GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005770; C:late endosome; ISS:UniProtKB.
 GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0005764; C:lysosome; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0030169; F:low-density lipoprotein particle binding; IDA:MGI.
 GO:0005041; F:low-density lipoprotein receptor activity; IDA:MGI.
 GO:0030229; F:very-low-density lipoprotein particle receptor activity; IDA:MGI.
 GO:0042632; P:cholesterol homeostasis; IMP:MGI.
 GO:0070508; P:cholesterol import; IMP:BHF-UCL.
 GO:0008203; P:cholesterol metabolic process; IMP:MGI.
 GO:0042159; P:lipoprotein catabolic process; IDA:MGI.
 GO:0034383; P:low-density lipoprotein particle clearance; IMP:BHF-UCL.
 GO:0015914; P:phospholipid transport; IMP:BHF-UCL.
 GO:0010867; P:positive regulation of triglyceride biosynthetic process; IMP:BHF-UCL.
 GO:0010899; P:regulation of phosphatidylcholine catabolic process; IMP:BHF-UCL. 
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR023415; LDLR_class-A_CS.
 IPR000033; LDLR_classB_rpt.
 IPR002172; LDrepeatLR_classA_rpt. 
Pfam
 PF07645; EGF_CA
 PF00057; Ldl_recept_a
 PF00058; Ldl_recept_b 
SMART
 SM00181; EGF
 SM00179; EGF_CA
 SM00192; LDLa
 SM00135; LY 
PROSITE
 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS01209; LDLRA_1
 PS50068; LDLRA_2
 PS51120; LDLRB 
PRINTS