UniProt Accession

 TRPV1_HUMAN; Q8NER1; A2RUA9; Q9H0G9; Q9H303; Q9H304; Q9NQ74; Q9NY22 

Genbank Protein ID

 AJ277028; AF196175; AF196176; AJ272063; AY131289; AL136801; AC027796; CH471108; BC132820; BC136633 

Genbank Nucleotide ID

 CAB95729.1; AAG43466.1; AAG43467.1; CAB89866.2; AAM89472.1; CAB66735.1; EAW90497.1; AAI32821.1; AAI36634.1 

Protein Name

 Transient receptor potential cation channel subfamily V member 1 

Protein Synonyms/Alias

 TrpV1; Capsaicin receptor; Osm-9-like TRP channel 1; OTRPC1; Vanilloid receptor 1 

Gene Name

 TRPV1 

Gene Synonyms/Alias

 VR1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
161	TGKTCLLKAMLNLHD	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity). 

Sequence Annotation

 REPEAT 111 153 ANK 1.
 REPEAT 154 200 ANK 2.
 REPEAT 201 247 ANK 3.
 REPEAT 248 283 ANK 4.
 REPEAT 284 332 ANK 5.
 REPEAT 333 359 ANK 6.
 REGION 685 713 AD (By similarity).
 REGION 768 802 Interaction with calmodulin (By
 REGION 778 793 Required for PIP2-mediated channel
 MOD_RES 117 117 Phosphoserine (By similarity).
 MOD_RES 145 145 Phosphothreonine (By similarity).
 MOD_RES 371 371 Phosphothreonine (By similarity).
 MOD_RES 502 502 Phosphoserine; by PKC/PRKCE (By
 MOD_RES 705 705 Phosphothreonine (By similarity).
 MOD_RES 775 775 Phosphoserine (By similarity).
 MOD_RES 801 801 Phosphoserine; by PKC/PRKCE (By
 MOD_RES 821 821 Phosphoserine (By similarity).
 CARBOHYD 604 604 N-linked (GlcNAc...) (By similarity).  

Keyword

 ANK repeat; ATP-binding; Calcium; Calcium channel; Calcium transport; Calmodulin-binding; Cell junction; Cell membrane; Cell projection; Complete proteome; Glycoprotein; Ion channel; Ion transport; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Postsynaptic cell membrane; Reference proteome; Repeat; Synapse; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 839 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0032591; C:dendritic spine membrane; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0045211; C:postsynaptic membrane; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005262; F:calcium channel activity; TAS:ProtInc.
 GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
 GO:0007635; P:chemosensory behavior; TAS:ProtInc.
 GO:0050955; P:thermoception; IDA:MGI. 

Interpro

 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR004729; TRP_channel.
 IPR008347; TRPV1-4_channel.
 IPR024863; TRPV1_channel.
 IPR024862; TRPV_channel. 

Pfam

 PF00023; Ank 

SMART

 SM00248; ANK 

PROSITE

 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 

PRINTS

 PR01768; TRPVRECEPTOR.