UniProt Accession

 CE57L_HUMAN; Q8IYX8 

Genbank Protein ID

 BC033448 

Genbank Nucleotide ID

 AAH33448.1 

Protein Name

 Centrosomal protein CEP57L1 

Protein Synonyms/Alias

 Centrosomal protein 57kDa-like protein 1; Centrosomal protein of 57 kDa-related protein; Cep57R; Cep57-related protein 

Gene Name

 CEP57L1 

Gene Synonyms/Alias

 C6orf182; CEP57R 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
91	SREAAQYKKALENET	acetylation	[1]
110	LAHQELIKQKKDISI	acetylation	[1]
286	RDPHILQKPFNVTET	ubiquitination	[2, 3]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Centrosomal protein which may be required for microtubule attachment to centrosomes (By similarity). 

Sequence Annotation

  

Keyword

 Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 460 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0034453; P:microtubule anchoring; IEA:InterPro. 

Interpro

 IPR010597; Centrosomal_protein_57kDa.
 IPR025913; Cep57_CLD.
 IPR024957; Cep57_MT-bd_dom. 

Pfam

 PF14073; Cep57_CLD
 PF06657; Cep57_MT_bd 

SMART

  

PROSITE

  

PRINTS