CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024763
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Interferon regulatory factor 2-binding protein 2 
Protein Synonyms/Alias
 IRF-2-binding protein 2; IRF-2BP2 
Gene Name
 Irf2bp2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
331ANGANGSKAVARTARubiquitination[1]
511CPSVPSHKFCFPCSRacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Acts as a transcriptional corepressor in a IRF2- dependent manner, this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle (By similarity). 
Sequence Annotation
 ZN_FING 489 536 RING-type; degenerate.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 169 169 Phosphoserine (By similarity).
 MOD_RES 343 343 Phosphoserine (By similarity).
 MOD_RES 438 438 Phosphoserine.
 MOD_RES 440 440 Phosphoserine.
 MOD_RES 443 443 Phosphoserine (By similarity).  
Keyword
 Acetylation; Activator; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 570 AA 
Protein Sequence
MAAAVAVAAA SRRQSCYLCD LPRMPWAMIW DFTEPVCRGC VNYEGADRVE FVIETARQLK 60
RAHGCFPEGR SPTGAQPAAA KPPPLSAKDL LLQPPPQLGH AGAEAARAQA MERYPLAPDR 120
APRLASDFST RAGAGLPQSA AQQSAPANGI LVPNGFSKLE EPPELNRQSP NPRRAHAVPP 180
TLVPLVNGSA ALGLSGRAAA TLAAVSGTPG LGAQPAELGT HKRPASVSSA AAEHEAREPS 240
KEKAQPAHRS PADSLSSAAG ASELSAEGAG KGRAPGEQDW ASRPKTVRDT LLALHQHGHS 300
GPFESKFKKE PALTAAGRLL GFEANGANGS KAVARTARKR KPSPEPEGEV GPPKINGETQ 360
PWLSTSTEGL KIPITPTSSF VSPPPPTASP HSNRTTPPEA AQNGQSPMAA LILVADNAGG 420
SHASKDATQV HSTTRRNSSS PPSPSSMNQR RLGPREVGGQ ATGSTGGLEP VHPASLPDSS 480
LAASAPLCCT LCHERLEDTH FVQCPSVPSH KFCFPCSRQS IKQQGASGEV YCPSGEKCPL 540
VGSNVPWAFM QGEIATILAG DVKVKKERDS 570 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR022750; Interferon_reg_fac2-bd1_2_Znf. 
Pfam
 PF11261; IRF-2BP1_2 
SMART
  
PROSITE
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS