CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014523
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synapsin-2 
Protein Synonyms/Alias
 Synapsin II 
Gene Name
 Syn2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
135AKCFRGKKILGDYDIubiquitination[1]
442QPQSGTLKEPDSSKTubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release (By similarity). 
Sequence Annotation
 REGION 1 29 A.
 REGION 33 113 B; linker.
 REGION 114 421 C; actin-binding and synaptic-vesicle
 REGION 422 458 G; Pro-rich linker.
 REGION 459 537 H; Pro/Ser-rich linker.
 REGION 538 586 E.
 MOD_RES 10 10 Phosphoserine; by PKA and CaMK1.
 MOD_RES 422 422 Phosphothreonine (By similarity).
 MOD_RES 426 426 Phosphoserine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Cell junction; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Synapse. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 586 AA 
Protein Sequence
MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQPPPAPGP GTATASAATS AASPGPERRP 60
PPAQAPAPQP APQPAPTPSV GSSFFSSLSQ AVKQTAASAG LVDAPAPSAA SRKAKVLLVV 120
DEPHTDWAKC FRGKKILGDY DIKVEQAEFS ELNLVAHADG TYAVDMQVLR NGTKVVRSFR 180
PDFVLIRQHA FGMAENEDFR HLVIGMQYAG LPSINSLESI YNFCDKPWVF AQMVAIFKTL 240
GGEKFPLIEQ TYYPNHREML TLPTFPVVVK IGHAHSGMGK VKVENHYDFQ DIASVVALTQ 300
TYATAEPFID AKYDIRVQKI GNNYKAYMRT SISGNWKTNT GSAMLEQIAM SDRYKLWVDA 360
CSEMFGGLDI CAVKAVHGKD GKDYIFEVMD CSMPLIGEHQ VEDRQLITDL VISKMNQLLS 420
RTPALSPQRP LTTQQPQSGT LKEPDSSKTP PQRPAPQGGP GQPQGMQPPG KVLPPRRLPS 480
GPSLPPSSSS SSSSSSSSSA PQRPGGPTST QVNASSSSNS LAEPQAPQAA PPQKPQPHPQ 540
LNKSQSLTNA FSFSESSFFR SSANEDEAKA ETIRSLRKSF ASLFSD 586 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0008021; C:synaptic vesicle; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0008092; F:cytoskeletal protein binding; TAS:RGD.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:0007269; P:neurotransmitter secretion; IEA:InterPro.
 GO:0046928; P:regulation of neurotransmitter secretion; TAS:RGD. 
Interpro
 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR016185; PreATP-grasp_dom.
 IPR001359; Synapsin.
 IPR020898; Synapsin_ATP-bd_dom.
 IPR019735; Synapsin_CS.
 IPR019736; Synapsin_P_site.
 IPR020897; Synapsin_pre-ATP-grasp_dom. 
Pfam
 PF02078; Synapsin
 PF02750; Synapsin_C
 PF10581; Synapsin_N 
SMART
  
PROSITE
 PS00415; SYNAPSIN_1
 PS00416; SYNAPSIN_2 
PRINTS
 PR01368; SYNAPSIN.