UniProt Accession

 ARGR_ECOLI; P0A6D0; P15282; Q2M8X6 

Genbank Protein ID

 X13968; M17532; U18997; U00096; AP009048 

Genbank Nucleotide ID

 CAA32148.1; AAA23486.1; AAA58039.1; AAC76269.1; BAE77280.1 

Protein Name

 Arginine repressor 

Protein Synonyms/Alias

  

Gene Name

 argR 

Gene Synonyms/Alias

 xerA; b3237; JW3206 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
12	AKQEELVKAFKALLK	acetylation	[1]
15	EELVKAFKALLKEEK	acetylation	[1]
19	KAFKALLKEEKFSSQ	acetylation	[1]
45	FDNINQSKVSRMLTK	acetylation	[1]
52	KVSRMLTKFGAVRTR	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Negatively controls the expression of the four operons of arginine biosynthesis in addition to the carAB operon. Predominantly interacts with A/T residues in ARG boxes. It also binds to a specific site in cer locus. Thus it is essential for cer-mediated site-specific recombination in ColE1. It is necessary for monomerization of the plasmid ColE1. 

Sequence Annotation

  

Keyword

 3D-structure; Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome; Cytoplasm; DNA recombination; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 156 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0034618; F:arginine binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:HAMAP.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:EcoCyc.
 GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:2000143; P:negative regulation of DNA-dependent transcription, initiation; IDA:EcoCyc.
 GO:0042150; P:plasmid recombination; IMP:EcoliWiki.
 GO:0051259; P:protein oligomerization; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001669; Arg_repress.
 IPR020899; Arg_repress_C.
 IPR024946; Arg_repress_C-like.
 IPR020900; Arg_repress_DNA-bd.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF01316; Arg_repressor
 PF02863; Arg_repressor_C 

SMART

  

PROSITE

  

PRINTS

 PR01467; ARGREPRESSOR.