| Tag | Content |
|---|
| CPLM ID | CPLM-014334 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Visual system homeobox 2 |
Protein Synonyms/Alias | Ceh-10 homeodomain-containing homolog; Homeobox protein CHX10 |
Gene Name | Vsx2 |
Gene Synonyms/Alias | Chx10 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 11 | KAGEALSKPKSETVA | acetylation | [1] |
|
Reference | [1] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y. Mol Cell. 2006 Aug;23(4):607-18. [ PMID: 16916647] |
Functional Description | Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells. |
Sequence Annotation | DOMAIN 208 261 CVC.
DNA_BIND 148 207 Homeobox.
MOTIF 304 317 OAR.
MOD_RES 11 11 N6-acetyllysine. |
Keyword | Acetylation; Complete proteome; Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 361 AA |
Protein Sequence | MTGKAGEALS KPKSETVAKS TSGGAPARCT GFGIQEILGL NKEPPSSHPR AALDGLAPGH 60
LLAARSVLSP AGVGSMGLLG PGGLPGFYTQ PTFLEVLSDP QSVHLQPLGR ASGPLDTSQT 120
ASSDSEDVSS SDRKMSKSAL NQTKKRKKRR HRTIFTSYQL EELEKAFNEA HYPDVYAREM 180
LAMKTELPED RIQVWFQNRR AKWRKREKCW GRSSVMAEYG LYGAMVRHSI PLPESILKSA 240
KDGIMDSCAP WLLGMHKKSL EAAAESGRKP EVERQALPKL DKMEQEERAP EAQAAISQEE 300
LRENSIAALR AKAQEHSTKV LGTVSGPDSL ARNAEKPEEE DATEEDRPAE KLSPPQLEDM 360
A 361 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:MGI. GO:0005730; C:nucleolus; IEA:Compara. GO:0005634; C:nucleus; IDA:MGI. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0045165; P:cell fate commitment; IMP:MGI. GO:0008285; P:negative regulation of cell proliferation; IMP:MGI. GO:0008284; P:positive regulation of cell proliferation; IMP:MGI. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. GO:0060040; P:retinal bipolar neuron differentiation; IMP:MGI. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
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PROSITE | |
PRINTS | |