UniProt Accession

 ISPD_ECOLI; Q46893; Q2MA82 

Genbank Protein ID

 AF230736; AB037143; U29579; U00096; AP009048 

Genbank Nucleotide ID

 AAF43207.1; BAA90761.1; AAA69257.1; AAC75789.1; BAE76824.1 

Protein Name

 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 

Protein Synonyms/Alias

 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; CDP-ME synthase; MEP cytidylyltransferase; MCT 

Gene Name

 ispD 

Gene Synonyms/Alias

 ygbP; b2747; JW2717 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
27	RMQTECPKQYLSIGN	acetylation	[1]
213	EGRADNIKVTRPEDL	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP). 

Sequence Annotation

  

Keyword

 3D-structure; Cobalt; Complete proteome; Direct protein sequencing; Isoprene biosynthesis; Magnesium; Manganese; Nucleotidyltransferase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 236 AA 

Protein Sequence

Gene Ontology

 GO:0050518; F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity; IDA:EcoCyc.
 GO:0019288; P:isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway; IEA:UniProtKB-UniPathway.
 GO:0016114; P:terpenoid biosynthetic process; IEA:HAMAP.
 GO:0006744; P:ubiquinone biosynthetic process; IDA:EcoCyc. 

Interpro

 IPR001228; ISPD_synthase.
 IPR018294; ISPD_synthase_CS. 

Pfam

 PF01128; IspD 

SMART

  

PROSITE

 PS01295; ISPD 

PRINTS