CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021233
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pseudouridylate synthase 7 homolog-like protein 
Protein Synonyms/Alias
  
Gene Name
 PUS7L 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
341YAGLKDKKAITYQAMubiquitination[1]
388SLRLGQLKGNHFDIVubiquitination[1]
401IVIRNLKKQINDSANubiquitination[1]
421MEAIENVKKKGFVNYubiquitination[1]
422EAIENVKKKGFVNYYubiquitination[1]
423AIENVKKKGFVNYYGubiquitination[1]
485FLQTEDAKGTLSLMPubiquitination[1]
634RFKVPTLKLNIPGCYubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 DOMAIN 424 647 TRUD.
 ACT_SITE 339 339 Nucleophile (By similarity).
 MOD_RES 127 127 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Isomerase; Phosphoprotein; Polymorphism; Reference proteome; tRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 701 AA 
Protein Sequence
MEEDTDYRIR FSSLCFFNDH VGFHGTIKSS PSDFIVIEID EQGQLVNKTI DEPIFKISEI 60
QLEPNNFPKK PKLDLQNLSL EDGRNQEVHT LIKYTDGDQN HQSGSEKEDT IVDGTSKCEE 120
KADVLSSFLD EKTHELLNNF ACDVREKWLS KTELIGLPPE FSIGRILDKN QRASLHSAIR 180
QKFPFLVTVG KNSEIVVKPN LEYKELCHLV SEEEAFDFFK YLDAKKENSK FTFKPDTNKD 240
HRKAVHHFVN KKFGNLVETK SFSKMNCSAG NPNVVVTVRF REKAHKRGKR PLSECQEGKV 300
IYTAFTLRKE NLEMFEAIGF LAIKLGVIPS DFSYAGLKDK KAITYQAMVV RKVTPERLKN 360
IEKEIEKKRM NVFNIRSVDD SLRLGQLKGN HFDIVIRNLK KQINDSANLR ERIMEAIENV 420
KKKGFVNYYG PQRFGKGRKV HTDQIGLALL KNEMMKAIKL FLTPEDLDDP VNRAKKYFLQ 480
TEDAKGTLSL MPEFKVRERA LLEALHRFGM TEEGCIQAWF SLPHSMRIFY VHAYTSKIWN 540
EAVSYRLETY GARVVQGDLV CLDEDIDDEN FPNSKIHLVT EEEGSANMYA IHQVVLPVLG 600
YNIQYPKNKV GQWYHDILSR DGLQTCRFKV PTLKLNIPGC YRQILKHPCN LSYQLMEDHD 660
IDVKTKGSHI DETALSLLIS FDLDASCYAT VCLKEIMKHD V 701 
Gene Ontology
 GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
 GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR020103; PsdUridine_synth_cat_dom.
 IPR001656; PsdUridine_synth_TruD.
 IPR017091; PsdUridine_synth_TruD_euk. 
Pfam
 PF01142; TruD 
SMART
  
PROSITE
 PS50984; TRUD
 PS01268; UPF0024 
PRINTS