| Tag | Content |
|---|
| CPLM ID | CPLM-024729 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Splicing factor, suppressor of white-apricot homolog |
Protein Synonyms/Alias | Splicing factor, arginine/serine-rich 8; Suppressor of white apricot protein homolog |
Gene Name | Sfswap |
Gene Synonyms/Alias | Sfrs8; Srsf8; Swap |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 315 | SRLEELMKPLKVVDP | acetylation | [1] | | 929 | ITQDLMAKVRAMLAA | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors (By similarity). Represses the splicing of MAPT/Tau exon 10. |
Sequence Annotation | REPEAT 211 253 SURP motif 1.
REPEAT 458 498 SURP motif 2.
MOD_RES 283 283 Phosphoserine (By similarity).
MOD_RES 315 315 N6-acetyllysine (By similarity).
MOD_RES 601 601 Phosphoserine (By similarity).
MOD_RES 639 639 Phosphothreonine (By similarity).
MOD_RES 903 903 Phosphoserine (By similarity). |
Keyword | Acetylation; Coiled coil; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; RNA-binding; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 945 AA |
Protein Sequence | MYGAGGGRAK AERKGGVKEE AGPGGTGTGG NRVELLVFGY ACKLFRDDER ALAQEQGQHL 60
IPWMGDHKIL IDRYDGRGHL HDLSAYDAEY ATWNRDYQLS EEEARVEALC DEERYLALHT 120
DLLEEEARQE EEYKRLSEAL AEDGNYSAVG FTYGSDYYDP SEPTEEEEPS KQREKSEAEN 180
LEENEEPFIA PLGLSVPSDV ELPPTAKMHA IIERTANFVC KQGAQFEIML KAKQARNSQF 240
DFLRFDHYLN PYYKFIQKAM KEGRYTVLAE SKSEEKKKSG PTSDNEEEDD EEDGSYLHPS 300
LFASKKSSRL EELMKPLKVV DPDHPLAALV RKAQADSSAP APPTADGTPA QPSQVEYTAD 360
STVAAMYYSY YMLPDGTYCL APPPPGIDVA TYYSTLPAGV TVSSSPGVTT TVPPPPGTTP 420
PPPPTTAESS SGVTSTTTTT SALAPVAIIP PPPDIQPVID KLAEYVARNG LKFETSVRAK 480
NDQRFEFLQP WHQYNAYYEF KKQFFLQKEG GGSTQAASTA EEAPTETAVE ESSEAGEDGA 540
PEGMAETGGR GSGKKEAGSS KSTVDGKLVK ASFAPISFAI KAKENDLLPL EKNRVKLDDD 600
SEEDEESREC QESTSSVANP SPAAAPPSAV VEEKKPQLTQ EELEAKQAKQ KLEDRLAAAA 660
REKLAQASKE SKEKQLQAER KRKAALFLQT LKNPLPDAEV GKLEESTFGV EETGVMPCPL 720
LVGGRTLPML EGKPPERPSS RCRDPPREEE REKKKKKHKK RSRTRSRSPK YHSSSKPRSR 780
SHSKAKHSLP SAYRTVRRSR SRSRSPRRRA HSPERRREDR SVPTAYRMSG SPGVSRKRTR 840
SRSPHEKKKK RRSRSRTKAK ARSQSTSPSK QAAQRPSAHS AHSASISPVE SRGSSQERSR 900
GVSQEKDGQI SSAIVSSVQS KITQDLMAKV RAMLAASKNL QTSAS 945 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. GO:0048025; P:negative regulation of mRNA splicing, via spliceosome; IDA:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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PROSITE | |
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