| Tag | Content |
|---|
| CPLM ID | CPLM-018226 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 2'-5'-oligoadenylate synthase-like protein 1 |
Protein Synonyms/Alias | 2',5'-oligoadenylate synthetase-like 9 |
Gene Name | Oasl1 |
Gene Synonyms/Alias | oasl9 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 378 | PIKKLKEKIQLSQGY | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L. |
Sequence Annotation | DOMAIN 350 429 Ubiquitin-like 1.
DOMAIN 430 506 Ubiquitin-like 2. |
Keyword | Antiviral defense; Complete proteome; Cytoplasm; Immunity; Innate immunity; Nucleus; Reference proteome; Repeat; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 511 AA |
Protein Sequence | MAVAQELYGF PASKLDSFVA QWLQPTREWK EEVLETVQTV EQFLRQENFR EDRGPARDVR 60
VLKVLKVGCF GNGTVLRSTT DVELVVFLSC FHSFQEEAKH HQAVLRLIQK RMYYCQELMD 120
LGLSNLSVTN RVPSSLIFTI QTRETWETIT VTVVPAYRAL GPSCPSSEVY ANLIKANGYP 180
GNFSPSFSEL QRNFVKHRPT KLKSLLRLVK HWYQQYVRDK CPRANLPPLY ALELLTVYAW 240
EAGTREDANF RLDEGLATVM ELLQDHELLC IYWTKHYTLQ HPVIEACVRR QLRGQRPIIL 300
DPADPTNNVA EGYRWDIVAQ RANQCLKQDC CYDNRDSPVP SWRVKRAPDI QVTVQEWGHS 360
DLTFWVNPYE PIKKLKEKIQ LSQGYLGLQR LSFQEPGGER QLIRSHCTLA YYGIFCDTHI 420
CLLDTISPEI QVFVKNPDGR SHAYAIHPLD YVLNLKQQIE DRQGLRCQEQ RLEFQGHILE 480
DWFDFKSYGI QDSVTVILSK TTEGAAPFVP S 511 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005730; C:nucleolus; ISS:UniProtKB. GO:0005524; F:ATP binding; IEA:InterPro. GO:0003677; F:DNA binding; ISS:UniProtKB. GO:0003725; F:double-stranded RNA binding; IDA:MGI. GO:0016740; F:transferase activity; IEA:InterPro. GO:0051607; P:defense response to virus; IEA:UniProtKB-KW. GO:0045087; P:innate immune response; IEA:UniProtKB-KW. GO:0045071; P:negative regulation of viral genome replication; IEA:Compara. GO:0009615; P:response to virus; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |