UniProt Accession

 D3YZ54_MOUSE; D3YZ54 

Genbank Protein ID

 AC109509 

Genbank Nucleotide ID

  

Protein Name

 2-hydroxyacyl-CoA lyase 1 

Protein Synonyms/Alias

  

Gene Name

 Hacl1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
21	EEQVSGAKVIAQALK	ubiquitination	[1]
112	EACRLYTKFSARPST	ubiquitination	[1]
129	LIPFIIEKAVRSSIY	ubiquitination	[1]
190	ASVLRDAKQPLLIIG	ubiquitination	[1]
198	QPLLIIGKGAAYSHA	ubiquitination	[1]
211	HAEDSIRKLVEQCSL	ubiquitination	[1]
227	FLPTPMGKGVVPDNH	ubiquitination	[1]
314	QLLEQFDKTPWQCPP	acetylation	[2]
327	PPDSQWWKTLREKMK	acetylation	[3]
327	PPDSQWWKTLREKMK	succinylation	[3]
334	KTLREKMKSNEAISK	acetylation	[3]
334	KTLREKMKSNEAISK	succinylation	[3]
341	KSNEAISKELASQKS	acetylation	[2, 3]
341	KSNEAISKELASQKS	succinylation	[3]
341	KSNEAISKELASQKS	ubiquitination	[1]
347	SKELASQKSLPMNYY	ubiquitination	[1]
527	QALQDTSKPCLLNIM	ubiquitination	[1]
542	IEPQSTRKAQDFHWL	acetylation	[3]
542	IEPQSTRKAQDFHWL	succinylation	[3]
542	IEPQSTRKAQDFHWL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 554 AA 

Protein Sequence

Gene Ontology

 GO:0005777; C:peroxisome; TAS:MGI.
 GO:0016829; F:lyase activity; IDA:MGI.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
 GO:0006629; P:lipid metabolic process; IDA:MGI. 

Interpro

 IPR012000; Thiamin_PyroP_enz_cen_dom.
 IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
 IPR011766; TPP_enzyme-bd_C. 

Pfam

 PF02775; TPP_enzyme_C
 PF00205; TPP_enzyme_M
 PF02776; TPP_enzyme_N 

SMART

  

PROSITE

  

PRINTS