UniProt Accession

 MBD3_HUMAN; O95983; A8K4B7; D6W5Z2; Q6PIL9; Q6PJZ9; Q86XF4 

Genbank Protein ID

 AF072247; AK290882; AC005943; CH471139; CH471139; CH471139; BC009372; BC009438; BC032443; BC043619 

Genbank Nucleotide ID

 AAC68876.1; BAF83571.1; AAC72104.1; EAW69477.1; EAW69478.1; EAW69481.1; AAH09372.1; AAH09438.1; AAH32443.1; AAH43619.1 

Protein Name

 Methyl-CpG-binding domain protein 3 

Protein Synonyms/Alias

 Methyl-CpG-binding protein MBD3 

Gene Name

 MBD3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
4	****MERKSPSGKKF	acetylation	[1]
9	ERKSPSGKKFRSKPQ	acetylation	[1]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. 

Sequence Annotation

 DOMAIN 1 72 MBD.
 MOD_RES 56 56 Phosphoserine.
 MOD_RES 85 85 Phosphoserine.
 MOD_RES 144 144 Phosphoserine.  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 291 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0000792; C:heterochromatin; IEA:Compara.
 GO:0016581; C:NuRD complex; NAS:BHF-UCL.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0016573; P:histone acetylation; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0006346; P:methylation-dependent chromatin silencing; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0009888; P:tissue development; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR016177; DNA-bd_integrase-typ.
 IPR025884; MeCpG-bd_2/3_C_dom.
 IPR001739; Methyl_CpG_DNA-bd. 

Pfam

 PF01429; MBD
 PF14048; MBD_C 

SMART

 SM00391; MBD 

PROSITE

 PS50982; MBD 

PRINTS