CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038133
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Microtubule-associated protein 
Protein Synonyms/Alias
  
Gene Name
 Map4 
Gene Synonyms/Alias
 Mtap4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
36ECGMDSRKEIGQDGFubiquitination[1]
658PKRPTSIKTEGKPADacetylation[2]
753TVSAPDLKSVRSKVGubiquitination[1]
811DVKIESQKLNFKEKAacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Microtubule; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 902 AA 
Protein Sequence
MSLPEKQPAA LTAALAAEDE QLSKGNPPEC GMDSRKEIGQ DGFEWQRTEG KLNEIGLNVS 60
MDGQLKDRLV KNSSFLEQNK LGFFEGKLDK ELSIEKPNKA YQETSGHLES GYVISGTCQP 120
SEGNLVHQKA AEFHPGLTEG KDKAATVQGK VAGKSGLEIK SQPDLNFPGA ADTLTQHGEE 180
QETSAWNANF YSVTQSPQAA TPGKEKNGLV SSCSVTGVMS DNSGQLNNKS PLLVAITHPD 240
PTSEHLPTTS PPITMVEFTQ ENLNAGQDKE LEKLRSSEEG PMLDQVPQQK KAIRRALSEC 300
YHLSVPPAVN LVDKYPELPA REELPSDLLP PTSSPMPSPM PRKLGVPAMR RSMTVAEDQS 360
ASCRLSAGEL ASLSASQVPT ALTFEEPVAK EREEQIHFSN DSNSSGKKEL GIAGLYLHSK 420
LEQIPEGSHK GKGQENTGET RVDSCPFICL GGEKQLMALA GKKEIEVTAT QSIPSLLLEE 480
TPRDGVSRQE EAKAAVGVTG NDITTPPNKE PPPSPEKKAK PLATTQPAKT STSKAKTQPT 540
SLPKQPAPTT SGGLNKKPMS LASGSVPAAP HKRPAAATAT ARPSTLPARD VKPKPITEAK 600
VAEKRTSPSK PSSAPALKPG PKTTPTVSKA TSPSTLVSTG PSSRSPATTL PKRPTSIKTE 660
GKPADVKRMT AKSASADLSR SKTTSASSVK RNTTPTGAAP PAGMTSTRVK PMSAPSRSSG 720
ALSVDKKPTS TKPSSSAPRV SRLATTVSAP DLKSVRSKVG STENIKHQPG GGRVQIQNKK 780
VDISKVSSKC GSKANIKHKP GGGDVKIESQ KLNFKEKAQA KVGSLDNVGH LPAGGAVKTE 840
GGGSEALPCP GPPAGEEPVI PEAAPDAGAP TSASGLSGHT TLSGGGDQRE PQTLDSQIQE 900
TN 902 
Gene Ontology
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0072686; C:mitotic spindle; ISO:MGI.
 GO:0008017; F:microtubule binding; IDA:MGI.
 GO:0051301; P:cell division; ISO:MGI.
 GO:0051294; P:establishment of spindle orientation; IDA:MGI.
 GO:0051012; P:microtubule sliding; IDA:MGI.
 GO:0007052; P:mitotic spindle organization; IDA:MGI. 
Interpro
 IPR027324; MAP2/MAP4/Tau.
 IPR027323; MAP4.
 IPR001084; Tau/MAP_tubulin-bd_rpt. 
Pfam
 PF00418; Tubulin-binding 
SMART
  
PROSITE
 PS00229; TAU_MAP_1
 PS51491; TAU_MAP_2 
PRINTS