CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015710
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative cystathionine beta-synthase Rv1077 
Protein Synonyms/Alias
 Beta-thionase; Serine sulfhydrase 
Gene Name
 cbs 
Gene Synonyms/Alias
 Rv1077; MT1108 
Created Date
 July 27, 2013 
Organism
 Mycobacterium tuberculosis 
NCBI Taxa ID
 1773 
Lysine Modification
Position
Peptide
Type
References
428ELVSAAGKALRDWDApupylation[1]
Reference
 [1] Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .
 Festa RA, McAllister F, Pearce MJ, Mintseris J, Burns KE, Gygi SP, Darwin KH.
 PLoS One. 2010 Jan 6;5(1):e8589. [PMID: 20066036] 
Functional Description
  
Sequence Annotation
 BINDING 74 74 Pyridoxal phosphate (By similarity).
 BINDING 269 269 Pyridoxal phosphate (By similarity).
 MOD_RES 44 44 N6-(pyridoxal phosphate)lysine (By
 CROSSLNK 428 428 Isoglutamyl lysine isopeptide (Lys-Gln)  
Keyword
 Complete proteome; Isopeptide bond; Lyase; Pyridoxal phosphate; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 464 AA 
Protein Sequence
MRIAQHISEL IGGTPLVRLN SVVPDGAGTV AAKVEYLNPG GSSKDRIAVK MIEAAEASGQ 60
LKPGGTIVEP TSGNTGVGLA LVAQRRGYKC VFVCPDKVSE DKRNVLIAYG AEVVVCPTAV 120
PPHDPASYYS VSDRLVRDID GAWKPDQYAN PEGPASHYVT TGPEIWADTE GKVTHFVAGI 180
GTGGTITGAG RYLKEVSGGR VRIVGADPEG SVYSGGAGRP YLVEGVGEDF WPAAYDPSVP 240
DEIIAVSDSD SFDMTRRLAR EEAMLVGGSC GMAVVAALKV AEEAGPDALI VVLLPDGGRG 300
YMSKIFNDAW MSSYGFLRSR LDGSTEQSTV GDVLRRKSGA LPALVHTHPS ETVRDAIGIL 360
REYGVSQMPV VGAEPPVMAG EVAGSVSERE LLSAVFEGRA KLADAVSAHM SPPLRMIGAG 420
ELVSAAGKAL RDWDALMVVE EGKPVGVITR YDLLGFLSEG AGRR 464 
Gene Ontology
 GO:0005618; C:cell wall; IDA:MTBBASE.
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005576; C:extracellular region; IDA:MTBBASE.
 GO:0005886; C:plasma membrane; IDA:MTBBASE.
 GO:0004122; F:cystathionine beta-synthase activity; IEA:EC.
 GO:0019343; P:cysteine biosynthetic process via cystathionine; IEA:InterPro. 
Interpro
 IPR005857; Cysta_beta_synth.
 IPR000644; Cysta_beta_synth_core.
 IPR001926; Trp_syn_b_sub_like_PLP_eny_SF. 
Pfam
 PF00571; CBS
 PF00291; PALP 
SMART
 SM00116; CBS 
PROSITE
 PS51371; CBS
 PS00901; CYS_SYNTHASE 
PRINTS