| Tag | Content |
|---|
| CPLM ID | CPLM-016363 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | PCI domain-containing protein 2 |
Protein Synonyms/Alias | CSN12-like protein |
Gene Name | Pcid2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 133 | LVKKGKSKVGDMLEK | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation. |
Sequence Annotation | DOMAIN 277 388 PCI.
MOD_RES 2 2 N-acetylalanine (By similarity). |
Keyword | Acetylation; Complete proteome; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 399 AA |
Protein Sequence | MAHITINQYL QQVYEAIDTR DGASCAELVS FKHPHVANPR LQMASPEEKC QQVLEPPYDE 60
MFAAHLRCTY AVGNHDFIEA YKCQTVIVQS FLRAFQAHKE ENWALPVMYA VALDLRIFAN 120
NADQQLVKKG KSKVGDMLEK AAELLMSCFR VCASDTRAGI EDSKKWGMLF LVNQLFKIYF 180
KINKLHLCKP LIRAIDSSNL KDDYSTAQRI TYKYYVGRKA MFDSDFKQAE EYLSFAFEHC 240
HRSSQKNKRM ILIYLLPVKM LLGHMPTIEL LRKYHLMQFS EVTKAVSEGN LLLLNEALAK 300
HETFFIRCGI FLILEKLKII TYRNLFKKVY LLLKTHQLSL DAFLVALKFM HVEDVDIDEV 360
QCILANLIYM GHIKGYISHQ HQKLVVSKQN PFPPLSTVC 399 |
Gene Ontology | GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB. GO:2000117; P:negative regulation of cysteine-type endopeptidase activity; IEA:Compara. GO:0045579; P:positive regulation of B cell differentiation; IMP:UniProtKB. GO:0090267; P:positive regulation of mitotic cell cycle spindle assembly checkpoint; IMP:UniProtKB. GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB. GO:0043488; P:regulation of mRNA stability; ISS:UniProtKB. GO:0048536; P:spleen development; IMP:UniProtKB. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |