UniProt Accession

 RPC4_YEAST; P25441; D6VRJ8; Q12073 

Genbank Protein ID

 X63501; X97751; Z74199; BK006938 

Genbank Nucleotide ID

 CAA45073.1; CAA66340.1; CAA98725.1; DAA11708.1 

Protein Name

 DNA-directed RNA polymerase III subunit RPC4 

Protein Synonyms/Alias

 RNA polymerase III subunit C4; C53; DNA-directed RNA polymerase III 47 kDa polypeptide 

Gene Name

 RPC53 

Gene Synonyms/Alias

 RPC4; YDL150W; D1557 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
115	DLRRGFIKSEGSGSS	acetylation	[1]
266	LADLGLEKEFQSVDG	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for tRNA synthesis. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation. 

Sequence Annotation

 MOTIF 25 29 Nuclear localization signal (Potential).
 MOD_RES 137 137 Phosphoserine.
 MOD_RES 138 138 Phosphoserine.
 MOD_RES 178 178 Phosphoserine.
 MOD_RES 182 182 Phosphoserine.
 MOD_RES 224 224 Phosphoserine.
 MOD_RES 228 228 Phosphothreonine.
 MOD_RES 232 232 Phosphothreonine.  

Keyword

 Complete proteome; DNA-directed RNA polymerase; Nucleus; Phosphoprotein; Reference proteome; Transcription. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 422 AA 

Protein Sequence

Gene Ontology

 GO:0005666; C:DNA-directed RNA polymerase III complex; IDA:SGD.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
 GO:0042797; P:tRNA transcription from RNA polymerase III promoter; IDA:SGD. 

Interpro

 IPR007811; RNA_pol_III_Rpc4. 

Pfam

 PF05132; RNA_pol_Rpc4 

SMART

  

PROSITE

  

PRINTS