| Tag | Content |
|---|
| CPLM ID | CPLM-017747 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Two pore calcium channel protein 2 |
Protein Synonyms/Alias | Voltage-dependent calcium channel protein TPC2 |
Gene Name | TPCN2 |
Gene Synonyms/Alias | TPC2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 376 | VQLDSSHKQAMMEKV | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. |
Sequence Annotation | CARBOHYD 611 611 N-linked (GlcNAc...) (Potential).
CARBOHYD 618 618 N-linked (GlcNAc...) (Potential). |
Keyword | Calcium; Calcium channel; Calcium transport; Complete proteome; Glycoprotein; Ion channel; Ion transport; Lysosome; Membrane; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 752 AA |
Protein Sequence | MAEPQAESEP LLGGARGGGG DWPAGLTTYR SIQVGPGAAA RWDLCIDQAV VFIEDAIQYR 60
SINHRVDASS MWLYRRYYSN VCQRTLSFTI FLILFLAFIE TPSSLTSTAD VRYRAAPWEP 120
PCGLTESVEV LCLLVFAADL SVKGYLFGWA HFQKNLWLLG YLVVLVVSLV DWTVSLSLVC 180
HEPLRIRRLL RPFFLLQNSS MMKKTLKCIR WSLPEMASVG LLLAIHLCLF TMFGMLLFAG 240
GKQDDGQDRE RLTYFQNLPE SLTSLLVLLT TANNPDVMIP AYSKNRAYAI FFIVFTVIGS 300
LFLMNLLTAI IYSQFRGYLM KSLQTSLFRR RLGTRAAFEV LSSMVGEGGA FPQAVGVKPQ 360
NLLQVLQKVQ LDSSHKQAMM EKVRSYGSVL LSAEEFQKLF NELDRSVVKE HPPRPEYQSP 420
FLQSAQFLFG HYYFDYLGNL IALANLVSIC VFLVLDADVL PAERDDFILG ILNCVFIVYY 480
LLEMLLKVFA LGLRGYLSYP SNVFDGLLTV VLLVLEISTL AVYRLPHPGW RPEMVGLLSL 540
WDMTRMLNML IVFRFLRIIP SMKLMAVVAS TVLGLVQNMR AFGGILVVVY YVFAIIGINL 600
FRGVIVALPG NSSLAPANGS APCGSFEQLE YWANNFDDFA AALVTLWNLM VVNNWQVFLD 660
AYRRYSGPWS KIYFVLWWLV SSVIWVNLFL ALILENFLHK WDPRSHLQPL AGTPEATYQM 720
TVELLFRDIL EEPGEDELTE RLSQHPHLWL CR 752 |
Gene Ontology | GO:0010008; C:endosome membrane; IDA:UniProtKB. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005765; C:lysosomal membrane; IDA:UniProtKB. GO:0072345; F:NAADP-sensitive calcium-release channel activity; IDA:UniProtKB. GO:0005245; F:voltage-gated calcium channel activity; ISS:UniProtKB. GO:0006874; P:cellular calcium ion homeostasis; IDA:UniProtKB. GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Compara. GO:0006939; P:smooth muscle contraction; ISS:UniProtKB. |
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SMART | |
PROSITE | |
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