UniProt Accession

 TR10A_HUMAN; O00220; A8K5I4; Q53Y72; Q96E62 

Genbank Protein ID

 U90875; BT006906; AK291299; EF064713; AC100861; BC012866 

Genbank Nucleotide ID

 AAC51226.1; AAP35552.1; BAF83988.1; ABK41896.1; AAH12866.1 

Protein Name

 Tumor necrosis factor receptor superfamily member 10A 

Protein Synonyms/Alias

 Death receptor 4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1; CD261 

Gene Name

 TNFRSF10A 

Gene Synonyms/Alias

 APO2; DR4; TRAILR1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
36	AAAATPSKVWGSSAG	ubiquitination	[1, 2]
191	RNTACQCKPGTFRND	ubiquitination	[3]
391	MRQLDLTKNEIDVVR	ubiquitination	[1]
443	EERHAREKIQDLLVD	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. 

Sequence Annotation

 REPEAT 107 145 TNFR-Cys 1.
 REPEAT 147 188 TNFR-Cys 2.
 REPEAT 189 229 TNFR-Cys 3.
 DOMAIN 365 448 Death.
 MOD_RES 463 463 Phosphoserine.
 MOD_RES 466 466 Phosphoserine.
 CARBOHYD 156 156 N-linked (GlcNAc...) (Potential).
 DISULFID 132 145 By similarity.
 DISULFID 148 164 By similarity.
 DISULFID 167 180 By similarity.
 DISULFID 170 188 By similarity.
 DISULFID 190 204 By similarity.
 DISULFID 207 221 By similarity.
 DISULFID 211 229 By similarity.  

Keyword

 Apoptosis; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 468 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IC:UniProtKB.
 GO:0005035; F:death receptor activity; TAS:ProtInc.
 GO:0045569; F:TRAIL binding; NAS:UniProtKB.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; NAS:UniProtKB.
 GO:0007250; P:activation of NF-kappaB-inducing kinase activity; NAS:UniProtKB.
 GO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB.
 GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; NAS:UniProtKB.
 GO:0006917; P:induction of apoptosis; NAS:UniProtKB. 

Interpro

 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR001368; TNFR/NGFR_Cys_rich_reg.
 IPR020465; TNFR_10. 

Pfam

 PF00531; Death
 PF00020; TNFR_c6 

SMART

 SM00005; DEATH
 SM00208; TNFR 

PROSITE

 PS50017; DEATH_DOMAIN
 PS00652; TNFR_NGFR_1
 PS50050; TNFR_NGFR_2 

PRINTS

 PR01956; TNFACTORR10.