CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014288
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Scavenger receptor class B member 1 
Protein Synonyms/Alias
 SRB1; SR-BI 
Gene Name
 Scarb1 
Gene Synonyms/Alias
 Srb1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
479LFWSGSKKGSQDKEAubiquitination[1]
500SLMSPAAKGTVLQEAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (By similarity). Plays an important role in the uptake of HDL cholesteryl ester (By similarity). 
Sequence Annotation
 CARBOHYD 102 102 N-linked (GlcNAc...) (Potential).
 CARBOHYD 108 108 N-linked (GlcNAc...) (Potential).
 CARBOHYD 116 116 N-linked (GlcNAc...) (Potential).
 CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
 CARBOHYD 212 212 N-linked (GlcNAc...) (Potential).
 CARBOHYD 227 227 N-linked (GlcNAc...) (Potential).
 CARBOHYD 255 255 N-linked (GlcNAc...) (Potential).
 CARBOHYD 288 288 N-linked (GlcNAc...) (Potential).
 CARBOHYD 310 310 N-linked (GlcNAc...) (Potential).
 CARBOHYD 330 330 N-linked (GlcNAc...) (Potential).
 CARBOHYD 383 383 N-linked (GlcNAc...) (Potential).
 DISULFID 251 384 Probable.  
Keyword
 Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 509 AA 
Protein Sequence
MGGSSRARWV ALGLGALGLL FAALGVVMIL MVPSLIKQQV LKNVRIDPSS LSFGMWKEIP 60
VPFYLSVYFF EVVNPNEVLN GQKPVVRERG PYVYREFRQK VNITFNDNDT VSFVENRSLH 120
FQPDKSHGSE SDYIVLPNIL VLGGSILMES KPVSLKLMMT LALVTMGQRA FMNRTVGEIL 180
WGYDDPFVHF LNTYLPDMLP IKGKFGLFVG MNNSNSGVFT VFTGVQNFSR IHLVDKWNGL 240
SKIDYWHSEQ CNMINGTSGQ MWAPFMTPES SLEFFSPEAC RSMKLTYNES RVFEGIPTYR 300
FTAPDTLFAN GSVYPPNEGF CPCRESGIQN VSTCRFGAPL FLSHPHFYNA DPVLSEAVLG 360
LNPNPKEHSL FLDIHPVTGI PMNCSVKMQL SLYIKSVKGI GQTGKIEPVV LPLLWFEQSG 420
AMGGKPLSTF YTQLVLMPQV LHYAQYVLLG LGGLLLLVPI ICQLRSQEKC FLFWSGSKKG 480
SQDKEAIQAY SESLMSPAAK GTVLQEAKL 509 
Gene Ontology
 GO:0005901; C:caveola; IDA:MGI.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; IDA:MGI.
 GO:0031528; C:microvillus membrane; IEA:Compara.
 GO:0008035; F:high-density lipoprotein particle binding; IDA:BHF-UCL.
 GO:0070506; F:high-density lipoprotein particle receptor activity; ISS:BHF-UCL.
 GO:0001530; F:lipopolysaccharide binding; IEA:Compara.
 GO:0001875; F:lipopolysaccharide receptor activity; IEA:Compara.
 GO:0030169; F:low-density lipoprotein particle binding; ISS:BHF-UCL.
 GO:0051856; P:adhesion to symbiont; IEA:Compara.
 GO:0006702; P:androgen biosynthetic process; IEA:Compara.
 GO:0043534; P:blood vessel endothelial cell migration; IMP:MGI.
 GO:0007155; P:cell adhesion; IEA:InterPro.
 GO:0006707; P:cholesterol catabolic process; IDA:MGI.
 GO:0033344; P:cholesterol efflux; IDA:BHF-UCL.
 GO:0042632; P:cholesterol homeostasis; IMP:BHF-UCL.
 GO:0070508; P:cholesterol import; IDA:BHF-UCL.
 GO:0032497; P:detection of lipopolysaccharide; IEA:Compara.
 GO:0001935; P:endothelial cell proliferation; IMP:MGI.
 GO:0034384; P:high-density lipoprotein particle clearance; ISS:BHF-UCL.
 GO:0034375; P:high-density lipoprotein particle remodeling; IMP:BHF-UCL.
 GO:0015920; P:lipopolysaccharide transport; IEA:Compara.
 GO:0034383; P:low-density lipoprotein particle clearance; IMP:BHF-UCL.
 GO:0015914; P:phospholipid transport; IMP:BHF-UCL.
 GO:0010886; P:positive regulation of cholesterol storage; ISS:BHF-UCL.
 GO:0051000; P:positive regulation of nitric-oxide synthase activity; IEA:Compara.
 GO:0010867; P:positive regulation of triglyceride biosynthetic process; IMP:BHF-UCL.
 GO:0043654; P:recognition of apoptotic cell; ISS:BHF-UCL.
 GO:0010899; P:regulation of phosphatidylcholine catabolic process; IMP:BHF-UCL.
 GO:0043691; P:reverse cholesterol transport; IMP:BHF-UCL.
 GO:0070328; P:triglyceride homeostasis; IMP:BHF-UCL. 
Interpro
 IPR002159; CD36.
 IPR005428; CD36_antigen. 
Pfam
 PF01130; CD36 
SMART
  
PROSITE
  
PRINTS
 PR01610; CD36ANTIGEN.
 PR01609; CD36FAMILY.