UniProt Accession

 CTND1_HUMAN; O60716; A8K939; O15088; O60713; O60714; O60715; O60935; Q6DHZ7; Q6RBX8; Q9UP71; Q9UP72; Q9UP73 

Genbank Protein ID

 AF062319; AF062323; AF062341; AF062342; AF062322; AF062326; AF062328; AF062338; AF062324; AF062327; AF062329; AF062330; AF062331; AF062333; AF062334; AF062335; AF062336; AF062339; AF062340; AF062343; AF062317; AF062325; AF062332; AF062344; AF062321; AF062320; AF062337; AF062318; AB002382; AK292554; AY505564; AP001931; BC075795 

Genbank Nucleotide ID

 AAC39804.1; AAC39808.1; AAC39826.1; AAC39827.1; AAC39807.1; AAC39811.1; AAC39813.1; AAC39823.1; AAC39809.1; AAC39812.1; AAC39814.1; AAC39815.1; AAC39816.1; AAC39818.1; AAC39819.1; AAC39820.1; AAC39821.1; AAC39824.1; AAC39825.1; AAC39828.1; AAC39802.1; AAC39810.1; AAC39817.1; AAC39829.1; AAC39806.1; AAC39805.1; AAC39822.1; AAC39803.1; BAA20838.2; BAF85243.1; AAR84236.1; AAH75795.1 

Protein Name

 Catenin delta-1 

Protein Synonyms/Alias

 Cadherin-associated Src substrate; CAS; p120 catenin; p120(ctn); p120(cas) 

Gene Name

 CTNND1 

Gene Synonyms/Alias

 KIAA0384 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
130	TLGRDFRKNGNGGPG	ubiquitination	[1]
301	ASLDSLRKGGPPPPN	ubiquitination	[1]
463	REPNEDCKPRHIEWE	ubiquitination	[1]
579	DEWFSRGKKPIEDPA	ubiquitination	[1]
580	EWFSRGKKPIEDPAN	ubiquitination	[1]
594	NDTVDFPKRTSPARG	ubiquitination	[1]
656	RSALRQEKALSAIAD	ubiquitination	[1]
844	SNMGSNTKSLDNNYS	ubiquitination	[1]
876	LGDMEPLKGTTPLMQ	ubiquitination	[1, 2, 3]
884	GTTPLMQKI******	ubiquitination	[1, 3]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. 

Sequence Annotation

 REPEAT 358 395 ARM 1.
 REPEAT 398 437 ARM 2.
 REPEAT 441 475 ARM 3.
 REPEAT 476 516 ARM 4.
 REPEAT 534 573 ARM 5.
 REPEAT 583 624 ARM 6.
 REPEAT 653 693 ARM 7.
 REPEAT 700 739 ARM 8.
 REPEAT 740 780 ARM 9.
 REPEAT 781 826 ARM 10.
 MOTIF 622 634 Nuclear localization signal (By
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 4 4 Phosphoserine.
 MOD_RES 47 47 Phosphoserine.
 MOD_RES 112 112 Phosphotyrosine; by FYN.
 MOD_RES 228 228 Phosphotyrosine (By similarity).
 MOD_RES 230 230 Phosphoserine.
 MOD_RES 252 252 Phosphoserine (By similarity).
 MOD_RES 257 257 Phosphotyrosine (By similarity).
 MOD_RES 268 268 Phosphoserine.
 MOD_RES 269 269 Phosphoserine.
 MOD_RES 288 288 Phosphoserine; by PAK7/PAK5.
 MOD_RES 291 291 Phosphotyrosine (By similarity).
 MOD_RES 320 320 Phosphoserine.
 MOD_RES 346 346 Phosphoserine (By similarity).
 MOD_RES 349 349 Phosphoserine.
 MOD_RES 352 352 Phosphoserine.
 MOD_RES 811 811 Phosphoserine.
 MOD_RES 847 847 Phosphoserine.
 MOD_RES 857 857 Phosphoserine.
 MOD_RES 859 859 Phosphoserine.
 MOD_RES 864 864 Phosphoserine.
 MOD_RES 865 865 Phosphotyrosine (By similarity).
 MOD_RES 879 879 Phosphoserine.
 MOD_RES 904 904 Phosphotyrosine (By similarity).
 MOD_RES 916 916 Phosphothreonine.
 MOD_RES 920 920 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative initiation; Alternative splicing; Cell adhesion; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 968 AA 

Protein Sequence

Gene Ontology

 GO:0005913; C:cell-cell adherens junction; IEA:Compara.
 GO:0005911; C:cell-cell junction; IDA:UniProtKB.
 GO:0005829; C:cytosol; IMP:BHF-UCL.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0030496; C:midbody; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0034332; P:adherens junction organization; TAS:Reactome.
 GO:0007155; P:cell adhesion; NAS:ProtInc.
 GO:0034329; P:cell junction assembly; TAS:Reactome.
 GO:0016337; P:cell-cell adhesion; IEA:Compara.
 GO:0060690; P:epithelial cell differentiation involved in salivary gland development; IEA:Compara.
 GO:0030216; P:keratinocyte differentiation; IEA:Compara.
 GO:0001738; P:morphogenesis of a polarized epithelium; IEA:Compara.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IMP:BHF-UCL.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0007435; P:salivary gland morphogenesis; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000225; Armadillo. 

Pfam

 PF00514; Arm 

SMART

 SM00185; ARM 

PROSITE

 PS50176; ARM_REPEAT 

PRINTS