CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026612
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative uncharacterized protein DKFZp686A22123 
Protein Synonyms/Alias
  
Gene Name
 DKFZp686A22123 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
199KDPEATEKLLRYAQTubiquitination[1]
235RLEYALVKGIEKHIIubiquitination[1]
335TIVLATVKGDVHDIGubiquitination[1]
371TPCDKILKAALDHKAubiquitination[1]
419IGGATTSKTHTAVKIubiquitination[1]
425SKTHTAVKIAPRYSAubiquitination[1]
479QGHYESLKERRYLPLubiquitination[1]
578LNTLISQKKLRARGVubiquitination[1]
681DYSSIMVKALGDRLAubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
 REGION 414 415 Cobalamin-binding (By similarity).
 REGION 781 782 S-adenosyl-L-methionine binding (By
 METAL 339 339 Cobalt (cobalamin axial ligand) (By
 BINDING 528 528 S-adenosyl-L-methionine (By similarity).
 BINDING 726 726 S-adenosyl-L-methionine; via carbonyl
 BINDING 730 730 Cobalamin; via carbonyl oxygen (By  
Keyword
 Cobalamin; Cobalt; Metal-binding; S-adenosyl-L-methionine. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 819 AA 
Protein Sequence
GMLDGPSAMT RFCNLIASEP DIAKVPLCID SSNFAVIEAG LKCCQGKCIV NSISLKEGQA 60
TETDTKIRVC TRAYHLLVKK LGFNPNDIIF DPNILTIGTG MEEHNLYAIN FIHATKVIKE 120
TLPGARISGG LSNLSFSFRG MEAIREAMHG VFLYHAIKSG MDMGIVNAGN LPVYDDIHKE 180
LLQLCEDLIW NKDPEATEKL LRYAQTQGTG GKKVIQTDEW RNGPVEERLE YALVKGIEKH 240
IIEDTEEARL NQKKYPRPLN IIEGPLMNGM KIVGDLFGAG KMFLPQVIKS ARVMKKAVGH 300
LIPFMEKERE ETRVLNGTVE EEDPYQGTIV LATVKGDVHD IGKNIVGVVL GCNNFRVIDL 360
GVMTPCDKIL KAALDHKADI IGLSGLITPS LDEMIFVAKE MERLAIRIPL LIGGATTSKT 420
HTAVKIAPRY SAPVIHVLDA SKSVVVCSQL LDENLKDEYF EEIMEEYEDI RQGHYESLKE 480
RRYLPLSQAR KSGFQMDWLP EPHPVKPTFI GTQVFEDYDL QKLVDYIDWK PFFDVWQLRG 540
KYPNRGFPKI FNDKTVGGEA RKVYDDAHNM LNTLISQKKL RARGVVGFWP AQSIQDDIHL 600
YAEAAVPQAA EPIATFYGLR QQAEKDSAST EPYYCLSDFI APLHSGIRDY LGLFAVACFG 660
VEELSKAYED DGDDYSSIMV KALGDRLAEA FAEELHERVR RELWAYCGSE QLDVADLRRL 720
RYKGIRPAPG YPSQPDHTEK LTMWRLADIE QSTGIRLTES LAMAPASAVS GLYFSNLKSK 780
YFAVGKISKD QVEDYALRKN ISVAEVEKWL GPILGYDTD 819 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
 GO:0008705; F:methionine synthase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0042558; P:pteridine-containing compound metabolic process; IEA:InterPro. 
Interpro
 IPR003759; Cbl-bd_cap.
 IPR006158; Cobalamin-bd.
 IPR011005; Dihydropteroate_synth-like.
 IPR011822; MetH.
 IPR000489; Pterin-binding.
 IPR004223; VitB12-dep_Met_synth_activ_dom. 
Pfam
 PF02310; B12-binding
 PF02607; B12-binding_2
 PF02965; Met_synt_B12
 PF00809; Pterin_bind 
SMART
 SM01018; B12-binding_2 
PROSITE
 PS50974; ADOMET_ACTIVATION
 PS51332; B12_BINDING
 PS51337; B12_BINDING_NTER 
PRINTS